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RecruitingPhase 2

Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

Kardigan, Inc. · NCT07511361

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
140
US sites recruiting
12
Study start
June 23, 2026
Record last updated
October 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.

Being studied: Tonlamarsen; Placebo

Conditions: Hypertension; Acute Severe Hypertension; Hypertensive Emergency; Hypertensive Urgency

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Key Inclusion Criteria

  • Age 18 or older, body weight ≥ 50 kg with BMI ≤45.0 kg/m2
  • Ready for discharge or recently discharged from the hospital to home (within the past 7 days) during which evaluation and/or treatment of acute severe hypertension (documented SBP ≥ 180 mmHg and/or DBP ≥ 110 mmHg) occurred, as measured by a healthcare provider (HCP) within the 24 hours preceding hospitalization or during the initial 24 hours of hospitalization
  • At Screening and Randomization visit, average resting office systolic blood pressure ≥ 145 mmHg
  • Presence of established cardiovascular or renal disease

Key Exclusion Criteria

  • Has known history of secondary hypertension
  • Any malignancy requiring treatment within 5 years (except for basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix that has been successfully treated)
  • Has abnormal thyroid function with clinical significance
  • Recent hospitalization for stroke, myocardial infarction or coronary revascularization within 30 days prior to screening
  • History of and/or obvious clinical signs or symptoms of cirrhosis or other significant liver disease
  • Alanine aminotransferase or aspartate aminotransferase >2 x upper limit of normal
  • Most recent hospitalization was for non-cardiovascular or non-renal conditions

Recruiting US locations

  • Western Nephrology and Metabolic Bone Disease, PC - Arvada

    Arvada, CO 80002

    Site contact: Kardigan Clinical Study Information Team · +1-877-310-5135 · clinicaltrials@kardigan.bio

  • Homestead Associates in Research

    Homestead, FL 33033

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Progressive Medical Research

    Port Orange, FL 32127

    Site contact: Kardigan Clinical Study Information Team · +1-877-310-5135 · clinicaltrials@kardigan.bio

  • Eagle Clinical Research

    Chicago, IL 60621

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Henry Ford Hospital

    Detroit, MI 48202

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Research Innovations, LLC

    Beavercreek, OH 05431

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Cleveland Clinic

    Cleveland, OH 44195

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • OnSite Clinical Solutions, LLC

    Fort Mill, SC 29715

    Site contact: Kardigan Clinical Study Information Team · +1-877-310-5135 · clinicaltrials@kardigan.bio

  • Chattanooga Research & Medicine CHARM

    Chattanooga, TN 37404

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Laguna Clinical Research Associates

    Laredo, TX 78041

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Tapia Internal Medicine Clinic

    Paris, TX 75460

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Baylor Scott and White Research Institute - Temple

    Temple, TX 76502

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

Study contacts (from the official record)

  • Kardigan Clinical Study Information Team · +1-877-310-5135 · clinicaltrials@kardigan.bio
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Study of Efficacy and Safety of Tonlamarsen in Participants With a… (NCT07511361) | Bored Studies