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RecruitingAccepts healthy volunteersPhase 3

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

University of North Carolina, Chapel Hill · NCT06179004

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 3
Target enrollment
100
US sites recruiting
1
Study start
April 10, 2024
Record last updated
October 24, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Orthopedic wrist procedures often cause significant postoperative pain. A supraclavicular nerve block is an effective and proven method to help reduce postoperative pain and decrease opioid use around the time of upper extremity surgery. Liposomal bupivacaine (Exparel) has been approved for use around the brachial plexus, but its analgesic efficacy has limited data. The investigators' goal is to evaluate the effectiveness of Exparel as compared to plain bupivacaine. The investigators hope to ensure the quality of pain control around the time of distal radius fracture repair and reduce the variability of care at the investigators institution by prospectively and rigorously collecting perioperative data during this study.

Being studied: Liposomal bupivacaine; Bupivacaine Hydrochloride

Conditions: Distal Radius Fractures; Wrist Fractures

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age greater than or equal to 18
  • Scheduled for orthopedic wrist surgery at University of North Carolina at Chapel Hill.

Exclusion Criteria

  • Contraindications to regional anesthesia
  • Emergent surgery Open fractures will be treated emergently and will not allow adequate lead time for enrollment in this study. Also, open fractures are usually accompanied by other traumatic injuries that would confound the pain related outcomes in this study.
  • Significant peripheral neuropathy or neurological disorder affecting the upper extremity
  • Pregnancy Pregnant women have physiologic changes that make them more sensitive to local anesthetics. That would introduce a confounding element in interpreting the effectiveness of the peripheral nerve blocks being studied.
  • Cognitive or psychiatric condition that might affect patient assessment and/or inability to provide informed consent.

Recruiting US locations

  • UNC Chapel Hill

    Chapel Hill, NC 27514

    Site contact: Jay Schoenherr, MD · 919-951-5062 · Jay_Schoenherr@med.unc.edu

Study contacts (from the official record)

  • Jay Schoenherr, MD · 9199515062 · jay_schoenherr@med.unc.edu
All healthy volunteers studies in North Carolina →
Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal… (NCT06179004) | Bored Studies