Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

Inclusion Criteria for healthy participants:

• 18-65 years of age
• Capacity to provide informed consent form to participate in the study

Inclusion Criteria for participants with Major Depressive Disorder (MDD):

• 18-65 years of age
• Capacity to provide informed consent form to participate in the study
• Currently in a major depressive episode. Comorbid anxiety disorders and personality disorders will be allowed provided that MDD is the primary diagnosis.

Exclusion Criteria for all participants

• Meeting criteria, in the past or currently, for bipolar affective disorder, hypomania or mania.
• Meeting criteria, in the past or currently, for a primary psychotic disorder (e.g., schizophrenia).
• Neurological conditions with known structural brain lesions, e.g., intracranial masses, multiple sclerosis.
• Any personal history of seizures or a family history of epilepsy in a first-degree relative.
• Metal in the body that is ferromagnetic or metallic injury to the eyes.
• Implanted pacemakers, medication pumps, vagal stimulators, deep brain stimulators, or ventriculoperitoneal shunts, etc.
• Substance abuse or dependence that is current and active within the last six months, as indicated by self-report (e.g., heroin, cocaine, methamphetamines).
• Inability to meet the safety criteria for MRI scanning for any other reason.
• Severe or unstable medical illness.
• Currently pregnant, as assessed with urine pregnancy test in women of childbearing age.