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The Impact of an Evidence-Based Parenting Service on Maternal Sensitivity and Infant Cellular Aging in a Population of Under-Resourced Families

University of Washington · with WakeMed Health and Hospitals, National Institute of Nursing Research (NINR) · NCT06740266

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
250
US sites recruiting
1
Study start
December 13, 2024
Record last updated
February 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial study is to learn how stress in childhood, or Early Life Adversity (ELA), gets "under the skin" and influences long-term health. The investigators will test if the support given to parents of young children reduces childhood stress. The investigators will also test if the effects of mother's stress and Early Life Adversity can be passed down to children. Can it impact the child's long-term health? Researchers will compare the Promoting First Relationships® in Primary Care (PFR in PC) parenting program with Usual Care to see if PFR reduces mothers' stress, improves mother's sensitivity, and reduces accelerated cellular aging.

Participants will

  • Be randomized to receive PFR in PC or Usual Care. PFR in PC is an evidence-based 10-week home visiting service, with 2 extra sessions at the WakeMed pediatric clinic. Usual Care is the health care and general services offered to families at the WakeMed pediatric clinic.
  • Have in-home research visits at the start of the study (Time 1, T1), about 6 months later (Time 2, T2), and 12 months later (Time 3, T3). Information collected at these visits includes:
  • Answering questions about your background, past and current stress, physical and mental health, parenting behaviors, and child behavior problems (T1, T2, T3).
  • Being videotaped doing a short teaching activity.
  • Having a small amount of blood collected from the mother by finger prick (T1, T3).
  • Having a small amount of blood collected from the infant by heel stick (T1, T3).

Being studied: Promoting First Relationships in Primary Care (PFR-PC)

Conditions: Parent Child Relationship; Child Social-Emotional Development; Telomere Length; Epigenetic Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Biological mother of infant aged 3-12 months English- or Spanish-speaking Receiving Medicaid Their infant is receiving pediatric care at WakeMed

Exclusion Criteria

  • Experiencing an acute crisis (e.g. hospitalization, incarceration) Homeless or without stable enough housing for home visits Lacking access to a phone Previously received the Promoting First Relationships intervention

Recruiting US locations

  • WakeMed Health & Hospitals

    Raleigh, NC 27610

    Site contact: Carrie Dow-Smith, MD · CDOW-SMITH@wakemed.org

Study contacts (from the official record)

  • Monica Oxford, PhD · 206-685-6107 · mloxford@uw.edu
  • Mary Jane Lohr, MS · 1-206-616-3373 · mjlohr@uw.edu
All healthy volunteers studies in North Carolina →
The Impact of an Evidence-Based Parenting Service on Maternal… (NCT06740266) | Bored Studies