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RecruitingAccepts healthy volunteersEarly Phase 1

The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

Beth Israel Deaconess Medical Center · with Boston University Charles River Campus, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT06983730

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
28
US sites recruiting
2
Study start
January 26, 2026
Record last updated
February 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are:

  • How do the chemicals produced by the body change under conditions of higher versus lower heat stress?
  • What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

Being studied: Vitamin B3

Conditions: Heat Strain; Healthy Volunteer Study; Kidney Dysfunction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy volunteer
  • Any race
  • Estimated glomerular filtration rate greater than 90 ml/min/1.73m2
  • Urine albumin/creatinine ratio less than 30mg/g
  • Nonsmoker
  • No regular dietary supplements, particularly vitamin B3
  • Physically fit, defined as having a VO2 max of between 35 and 60mL/kg/min

Exclusion Criteria

  • Medical condition preventing safe participation in exercise during heat
  • Allergy to Vitamin B3
  • Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications

Recruiting US locations

  • Beth Israel Deaconess Medical Center

    Boston, MA 02215

    Site contact: Nathan H Raines, MD MPH · 703-927-0992 · nraines@bidmc.harvard.edu

  • Boston University

    Boston, MA 02215

    Site contact: Dustin Allen, PhD · 417-693-2182 · drallen@bu.edu

Study contacts (from the official record)

  • Nathan H Raines, MD MPH · 703-927-0992 · nraines@bidmc.harvard.edu
All nutrition & metabolism studies in Massachusetts →
The Kidney's Response to Exercise in Heat, and the Impact of… (NCT06983730) | Bored Studies