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The Vanguard Study: Testing a New Way to Screen for Cancer

National Cancer Institute (NCI) · NCT06995898

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 45–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
24000
US sites recruiting
45
Study start
June 18, 2025
Record last updated
October 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial. An MCD test measures markers in the blood in order to screen for multiple cancers simultaneously. There is a need to understand how MCDs may work as cancer screening tools. The goal of cancer screening is to reduce the burden of cancer by identifying cancers before they show symptoms or signs, when treatment is likely to be most effective. In this study, adults aged 45-75 without cancer will be randomly assigned to one of 3 groups: 2 separate MCD test groups or a control group. These two MCD tests will not be compared to each other but will be compared to cancers detected in the control group. This study will provide early information on how well MCD tests perform as cancer screening tools. It will also help researchers understand how patients and their doctors make decisions about their care when the MCD test result comes back as normal (negative) or abnormal (positive).

Being studied: Biospecimen Collection; Device Usage; Electronic Health Record Review; Multi-Cancer Detection Test; Multi-Cancer Detection Test; Questionnaire Administration

Conditions: Bladder Carcinoma; Breast Carcinoma; Colorectal Carcinoma; Esophageal Carcinoma; Gastric Carcinoma; Liver Carcinoma; Lung Carcinoma; Malignant Solid Neoplasm; Ovarian Carcinoma; Pancreatic Carcinoma; Prostate Carcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Ages 45-75 years old
  • Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment
  • Agree to allow collection of information from their medical records for study-related purposes
  • Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic
  • Note: Eligibility for Spanish and Arabic languages are at the Hub's discretion

Exclusion Criteria

  • Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years
  • Note: Persons with a history of in situ cancers (e.g., ductal carcinoma in situ of the breast, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ) or nonmelanoma skin cancer are eligible. Persons with a history of prostate cancer that has not been treated are not eligible, regardless of when the diagnosis occurred
  • Ongoing cancer diagnostic work-up
  • Ongoing participation in another study of an investigational cancer screening test or technology not currently utilized in routine clinical practice
  • Currently breastfeeding or pregnant, or planning to become pregnant in the next year
  • History of solid organ or hematopoietic transplantation at any time, or blood transfusion within the last 30 days

Recruiting US locations

  • Kaiser Permanente-Division of Research

    Pleasanton, CA 94588

    Site contact: Site Public Contact · 510-891-3400

  • Keefe Memorial Hospital

    Cheyenne Wells, CO 80810

    Site contact: Site Public Contact · 719-767-5661 · cmillsap@keefemh.org

  • Kaiser Permanente-Franklin

    Denver, CO 80205

    Site contact: Site Public Contact · 303-817-9295 · KPCOIHRClinicalResearch@kp.org

  • Poudre Valley Hospital

    Fort Collins, CO 80524

    Site contact: Site Public Contact · 970-297-6150

  • Cancer Care and Hematology-Fort Collins

    Fort Collins, CO 80528

    Site contact: Site Public Contact · 888-823-5923 · ctsucontact@westat.com

  • UCHealth Greeley Hospital

    Greeley, CO 80631

    Site contact: Site Public Contact · 888-823-5923 · ctsucontact@westat.com

  • Kaiser Permanente-Rock Creek

    Lafayette, CO 80026

    Site contact: Site Public Contact · 303-817-9295 · KPCOIHRClinicalResearch@kp.org

  • Kaiser Permanente-Lone Tree

    Lone Tree, CO 80124

    Site contact: Site Public Contact · 303-817-9295 · KPCOIHRClinicalResearch@kp.org

  • Medical Center of the Rockies

    Loveland, CO 80538

    Site contact: Site Public Contact · 970-203-7083

  • Kaiser Permanente Moanalua Medical Center

    Honolulu, HI 96819

    Site contact: Site Public Contact · 808-432-5195 · shelley.a.clark@kp.org

  • Walter Reed National Military Medical Center

    Bethesda, MD 20889-5600

    Site contact: Site Public Contact · 240-265-9823

  • Henry Ford Cancer Institute-Downriver

    Brownstown, MI 48183

    Site contact: Site Public Contact · 313-916-3721 · CTOResearch@hfhs.org

  • Henry Ford Health Center - Brownstown

    Brownstown, MI 48183

    Site contact: Site Public Contact · 313-874-5472 · CDUDAS1@hfhs.org

  • Henry Ford Health Center - Chesterfield

    Chesterfield, MI 48047

    Site contact: Site Public Contact · 313-874-5472 · CDUDAS1@hfhs.org

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, MI 48038

    Site contact: Site Public Contact · 313-916-3721 · CTOResearch@hfhs.org

  • Henry Ford Medical Center-Fairlane

    Dearborn, MI 48126

    Site contact: Site Public Contact · 313-916-3721 · CTOResearch@hfhs.org

  • Henry Ford Hospital

    Detroit, MI 48202

    Site contact: Site Public Contact · 313-916-3721 · CTOResearch@hfhs.org

  • Henry Ford Medical Center - Detroit Northwest

    Detroit, MI 48235

    Site contact: Site Public Contact · kkeenan1@hfhs.org

  • Henry Ford Medical Center-Cottage

    Grosse Pointe Farms, MI 48236

    Site contact: Site Public Contact · 313-916-1784

  • Henry Ford Medical Center - Livonia

    Livonia, MI 48150

    Site contact: Site Public Contact · kkeenan1@hfhs.org

  • Henry Ford Medical Center-Columbus

    Novi, MI 48377

    Site contact: Site Public Contact · 313-916-3721 · CTOResearch@hfhs.org

  • Henry Ford Medical Center - Plymouth

    Plymouth, MI 48170

    Site contact: Site Public Contact · kkeenan1@hfhs.org

  • Henry Ford Medical Center - Royal Oak

    Royal Oak, MI 48067

    Site contact: Site Public Contact · kkeenan1@hfhs.org

  • Henry Ford Medical Center

    Sterling Heights, MI 48310

    Site contact: Site Public Contact · 888-823-5923 · ctsucontact@westat.com

  • Henry Ford Medical Center - Troy

    Troy, MI 48083

    Site contact: Site Public Contact · kkeenan1@hfhs.org

  • Henry Ford West Bloomfield Hospital

    West Bloomfield, MI 48322

    Site contact: Site Public Contact · 313-916-3721 · CTOResearch@hfhs.org

  • Henry Ford Wyandotte Hospital

    Wyandotte, MI 48192

    Site contact: Site Public Contact · nhay@hfhs.org

  • Minneapolis VA Medical Center

    Minneapolis, MN 55417

    Site contact: Site Public Contact · 612-467-2800

  • Saint Luke's Hospital of Kansas City

    Kansas City, MO 64111

    Site contact: Site Public Contact · 913-948-5588 · aroland@kccop.org

  • CoxHealth South Hospital

    Springfield, MO 65807

    Site contact: Site Public Contact · 417-269-4520

  • Washington University School of Medicine

    St Louis, MO 63110

    Site contact: Site Public Contact · 800-600-3606 · info@siteman.wustl.edu

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, NC 27599

    Site contact: Site Public Contact · 877-668-0683 · cancerclinicaltrials@med.unc.edu

  • Durham VA Medical Center

    Durham, NC 27705

    Site contact: Site Public Contact · 919-286-0411 · VHADURcancertrials@va.gov

  • Louis Stokes Cleveland VA Medical Center

    Cleveland, OH 44106

    Site contact: Site Public Contact · holly.henry@va.gov

  • University of Oklahoma Health Sciences Center

    Oklahoma City, OK 73104

    Site contact: Site Public Contact · 405-271-8777 · ou-clinical-trials@ouhsc.edu

  • Sentara Martha Jefferson Hospital

    Charlottesville, VA 22911

    Site contact: Site Public Contact · 434-654-8400

  • Inova Schar Cancer Institute

    Fairfax, VA 22031

    Site contact: Site Public Contact · 703-720-5210 · Stephanie.VanBebber@inova.org

  • Inova Fair Oaks Hospital

    Fairfax, VA 22033

    Site contact: Site Public Contact · 703-720-5210 · Stephanie.VanBebber@inova.org

  • Sentara Norfolk General Hospital

    Norfolk, VA 23507

    Site contact: Site Public Contact · 757-388-2406

  • Naval Medical Center - Portsmouth

    Portsmouth, VA 23708-2197

    Site contact: Site Public Contact · 757-953-5939

  • VCU Massey Cancer Center at Stony Point

    Richmond, VA 23235

    Site contact: Site Public Contact · ctoclinops@vcu.edu

  • VCU Massey Comprehensive Cancer Center

    Richmond, VA 23298

    Site contact: Site Public Contact · 804-628-6430 · CTOclinops@vcu.edu

  • VCU Community Memorial Health Center

    South Hill, VA 23970

    Site contact: Site Public Contact · nemer.elmouallem@vcuhealth.org

  • Madigan Army Medical Center

    Tacoma, WA 98431

    Site contact: Site Public Contact · 253-968-6144 · melissa.a.forouhar.mil@health.mil

  • Zablocki Veterans Administration Medical Center

    Milwaukee, WI 53295

    Site contact: Site Public Contact · 888-469-6614

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The Vanguard Study: Testing a New Way to Screen for Cancer (NCT06995898) | Bored Studies