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RecruitingAccepts healthy volunteersPhase 2

Valacyclovir in Pain Management of Acute Apical Abscesses

University of California, San Francisco · NCT05266040

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
60
US sites recruiting
1
Study start
October 25, 2023
Record last updated
May 30, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The Virus in Endodontics (VE) phase I pilot study for preoperative pain will be analyzed and adjusted for the Phase II clinical trial. The Phase II clinical trial on preoperative pain, postoperative pain, and clinical healing will involve 250 patients. Patients will be recruited from the same pool of participants as the Phase II clinical trial. Preoperative cone beam computed tomography (CBCT) scans will be taken as well as three and six month postoperative CBCT scans. The secondary outcomes form the Phase II randomized clinical trial will be clinical success and visible radiographic healing determined by CBCT images.

Being studied: Valacyclovir 500 MG; Placebo

Conditions: Acute Apical Abscess; Pain, Acute

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Patient must be ≥ 18-year-old
  • Patient must be systemically healthy; American Society of Anesthesiologists (ASA) Class I or II
  • Patient must exhibit clinical evidence of pulp necrosis and acute apical abscess
  • Patient must present with radiographic
  • signs of apical disease either by
  • periapical radiography or cone-beam
  • computed tomography
  • Patient consented to receive conventional pulpal debridement, incision and drainage at the end of the study
  • Persistent pain of moderate or higher level (>4) was the main inclusion criterion. Pain assessed as follows: 0 defined as no pain, 1-3 as mild pain, 4-6 as moderate pain, and 7-10 as severe pain

Exclusion Criteria

  • Smokers (more than 10 cigarettes per day)
  • External or internal tooth resorption
  • Marginal periodontitis
  • Pregnant or nursing mothers (hormonal factors may influence the periapical condition)
  • Documented allergic or adverse reactions to amoxicillin or valacyclovir
  • Teeth with unusual anatomy or inaccurate clinical diagnosis on the day of treatment (i.e., partially necrotic pulp)
  • Patients currently taking antibiotics or antiviral medications

Recruiting US locations

  • UCSF Dental

    San Francisco, CA 94143

    Site contact: mike sabeti, DDS · 415-476-0822 · mike.sabeti@ucsf.edu

Study contacts (from the official record)

  • Mike Sabeti, DDS · 415-476-0822 · Mike.Sabeti@ucsf.edu
All pain studies in California →
Valacyclovir in Pain Management of Acute Apical Abscesses (NCT05266040) | Bored Studies