Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Validating Gulf War Illness Blood Biomarkers

Roskamp Institute Inc. · with Boston University, Palo Alto Veterans Institute for Research · NCT05736146

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 35+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
100
US sites recruiting
3
Study start
June 30, 2022
Record last updated
July 24, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.

Conditions: Gulf War Syndrome; Gulf War Illness

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age 35 years or older.
  • For GWI cases, served in the 1990-1991 Gulf War as active duty, national guard, or reserves and meet criteria for the CDC Chronic Multisymptom Illness (CMI) GWI definition or Kansas GWI definition.
  • For controls, must be a veteran in the same age range as those veterans with GWI as defined above.
  • Ability to understand written and spoken English or availability of a legal representative who can understand written or spoken English. Participants and caregiver/informants must be able to read, write and speak the language in which psychometric tests are provided with visual and auditory acuity (corrected) sufficient to allow for accurate testing.

Exclusion Criteria

  • Diagnosed or being treated by a physician for any of the following (Steele et al, 2000) and deemed clinically significant per the discretion of the PI:
  • Cancer (except for non-melanoma skin cancers)
  • Chronic infectious disease
  • Problems resulting from postwar injuries.
  • Liver disease
  • Lupus
  • Multiple sclerosis
  • Stroke
  • Serious psychiatric condition (those associated with psychosis and/or for which the respondent had been hospitalized since 1991).
  • Dementia or any type of Parkinson's disease (PD).
  • Hospitalized in the last 5 years for alcohol or drug dependence, depression, or post-traumatic stress disorder (PTSD).
  • Female subject is either pregnant or nursing.

Recruiting US locations

  • Palto Alto Veterans Institute for Research

    Palo Alto, CA 94304

    Site contact: Raj Brar · 650-374-9073 · RBrar@pavir.org

  • The Roskamp Institute

    Sarasota, FL 34232

    Site contact: Dakota M Helgager, B.S. · 941-256-8019 · dhelgager@roskampclinic.org

  • Boston University

    Boston, MA 02118

    Site contact: Leah Orlinsky · 617-358-2214 · bbrain@bu.edu

Study contacts (from the official record)

  • Dakota Helgager, B.S · (941) - 256 - 8019 · dhelgager@roskampclinic.org
All healthy volunteers studies in California →
Validating Gulf War Illness Blood Biomarkers (NCT05736146) | Bored Studies