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Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

Brigham and Women's Hospital · with Mclean Hospital, Beth Israel Deaconess Medical Center · NCT06105164

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
150
US sites recruiting
2
Study start
December 5, 2024
Record last updated
December 5, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals.

TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.

Being studied: Repetitive Transcranial Magnetic Stimulation (rTMS); Sham repetitive Transcranial Magnetic Stimulation (rTMS)

Conditions: Appetitive Behavior; Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy individuals aged 18 to 65
  • BMI of 20-35.0 kg/m2
  • Normal or corrected-to-normal vision
  • Good general health
  • Ability to understand and willingness to sign written informed consent document

Exclusion Criteria

  • Current and/or past medical conditions
  • Current and/or past eating disorder
  • On a restricted diet and/or taking weight loss medication(s)
  • History of bariatric surgery
  • Weight fluctuation >3% in past 3 months
  • Recent history of illicit recreational drug abuse
  • Current nicotine use
  • Intellectual disability
  • Conditions that might result in increased risks of side effects or complications from TMS or MRI

Recruiting US locations

  • McLean Hospital

    Belmont, MA 02478

    Site contact: Mark Halko, PhD · 617-855-2415 · mhalko@mclean.harvard.edu

  • Brigham and Women's Hospital

    Boston, MA 02120

    Site contact: Laura Holsen, PhD · 617-525-8772 · lholsen@bwh.harvard.edu

Study contacts (from the official record)

  • Laura Holsen, PhD · 617-525-8772 · lholsen@bwh.harvard.edu
  • Mark Halko, PhD · 617-855-2415 · mhalko@mclean.harvard.edu
All weight loss studies in Massachusetts →
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans (NCT06105164) | Bored Studies