Phase 1 · Boston area, MA
Phase 1 clinical trials in Boston area, MA
98 recruiting studies have a site in the Boston area. This page includes nearby cities such as Cambridge, Brookline, Newton, Waltham.
98 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersEarly Phase 1
Impulsivity Domains and Subjective Response
Jessica Weafer
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 21–25
- RecruitingHealthy volunteersEarly Phase 1
The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma
MCPHS University
- Location
- Worcester, MA
- Eligibility basics
- Ages 50–100
- RecruitingHealthy volunteersEarly Phase 1
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 40–99
- RecruitingHealthy volunteersPhase 1
Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
Positron Emission Tomography (PET) Imaging of Thrombosis
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersEarly Phase 1
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Beth Israel Deaconess Medical Center
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1/Phase 2
Molecular Imaging of NET Using [C-11]MRB-PET in MS
Brigham and Women's Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1/Phase 2
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
Brigham and Women's Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteersEarly Phase 1
Assessment of Synaptic Density in MS
Brigham and Women's Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersEarly Phase 1
An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus
D. Bradley Welling, MD, PhD
- Location
- Boston, MA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
Massachusetts Eye and Ear Infirmary
- Location
- Boston, MA
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1/Phase 2
Assess Fibrin in Brains With AD/ADRD
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 55–90
- RecruitingHealthy volunteersEarly Phase 1
Mapping Auricular Vagus Nerve Circuitry
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Benjamin Medoff
- Location
- Boston, MA
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in…
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
CRISPR Therapeutics
- Location
- Boston, MA + 7 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Cullinan Therapeutics Inc.
- Location
- Boston, MA + 10 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage
Astellas Pharma Global Development, Inc.
- Location
- Boston, MA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease
CRISPR Therapeutics AG
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease
Calico Life Sciences LLC
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 6 mo+
- RecruitingPhase 1/Phase 2
RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis
Cabaletta Bio
- Location
- Boston, MA + 16 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With…
Cabaletta Bio
- Location
- Boston, MA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of LY5830966 in Participants With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I…
Ajax Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company
- Location
- Boston, MA + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Ionis Pharmaceuticals, Inc.
- Location
- Boston, MA + 7 other US sites
- Eligibility basics
- Ages 2–65 · Men only
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.