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RecruitingPhase 2

A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

Centessa Pharmaceuticals (UK) Limited · NCT07096674

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
90
US sites recruiting
19
Study start
August 12, 2025
Record last updated
April 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study is a long-term extension (LTE) of the parent Study ORX750 0201, and will provide long-term open-label safety, tolerability, and efficacy of ORX750 in participants with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH).

Being studied: ORX750; ORX750; ORX750

Conditions: Narcolepsy Type 1; Narcolepsy Type 2; Idiopathic Hypersomnia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Diagnosis of narcolepsy (NT1 or NT2) or IH who was eligible for and completed the full treatment period in the eligible parent study ORX750-0201 (CRYSTAL-1)
  • Is willing and able to adhere to additional protocol requirements

Exclusion Criteria

  • Development of any new disease/disorder that in the opinion of the investigator would make the participant unable to continue the study
  • Unable to refrain from excluded medications, including those used for treatment of narcolepsy or idiopathic hypersomnia

Recruiting US locations

Study contacts (from the official record)

  • Orexin Centessa Program Lead · 617-468-5770 · ORX750-LTE@centessa.com
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A Long-term Extension Study of ORX750 in Participants With… (NCT07096674) | Bored Studies