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RecruitingAccepts healthy volunteersPhase 4

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age

BioNTech SE · with Pfizer · NCT07730450

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–64 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
200
US sites recruiting
5
Study start
July 23, 2026
Record last updated
August 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to learn about the safety and effects of an updated COVID-19 vaccine (called BNT162b2) in adults 18 to 64 years of age.

This study is seeking participants who

  • are medically stable
  • have not had a recent COVID-19 infection
  • have not had a recent vaccination
  • do not have medical conditions that increase their risk of complications from COVID-19

All participants in this study will randomly receive 1 injection into their arm of either:

  • BNT162b2 vaccine which targets COVID-19 and is selected for the 2026-2027 COVID-19 season, or
  • Tdap vaccine which targets tetanus, diphtheria, and pertussis (whooping cough).

The study team and participants will not know which injection they receive. We will evaluate safety and SARS-CoV-2 spike protein levels in people receiving each of these vaccines.

Participants will be in the study for about 12 months.

Being studied: BNT162b2 Vaccine; Tdap Vaccine

Conditions: COVID-19 Vaccines

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Key Inclusion Criteria

  • Healthy participants 18 through 64 years of age who do not have medical conditions that put them at a higher risk for severe COVID-19.

Key Exclusion Criteria

  • Participants who tested positive for COVID-19 within 6 months (180 days) prior to Visit 1
  • Participants who have recently received a vaccine, or plan to receive a nonstudy COVID-19 or comparator vaccine during participation.

The complete list of inclusion and exclusion criteria are listed in the protocol.

Recruiting US locations

Study contacts (from the official record)

  • Pfizer CT.gov Call Center · 1-800-718-1021 · ClinicalTrials.gov_Inquiries@pfizer.com
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A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18… (NCT07730450) | Bored Studies