Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Alliance for Clinical Trials in Oncology · with National Cancer Institute (NCI) · NCT05334069
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 40–75 · All sexes
- Healthy volunteers
- Accepted
- Study type
- Observational
- Target enrollment
- 2000
- US sites recruiting
- 613
- Study start
- August 18, 2022
- Record last updated
- October 2, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in the laboratory may help researchers develop tests for the early detection of cancers.
Being studied: Questionnaire Administration; Biospecimen Collection
Conditions: Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Ann Arbor Stage I Lymphoma; Ann Arbor Stage II Lymphoma; Ann Arbor Stage III Lymphoma; Ann Arbor Stage IV Lymphoma; Chronic Lymphocytic Leukemia; Chronic Myeloid Leukemia; Gastroesophageal Junction Adenocarcinoma; Head and Neck Carcinoma; Hematopoietic and Lymphoid Cell Neoplasm; Invasive Breast Carcinoma; Kidney Carcinoma; Malignant Hepatobiliary Neoplasm; Malignant Solid Neoplasm; Melanoma; Muscle-Invasive Bladder Carcinoma; RISS Stage I Plasma Cell Myeloma; RISS Stage II Plasma Cell Myeloma; RISS Stage III Plasma Cell Myeloma; Sarcoma; Stage I Bladder Cancer AJCC v6 and v7; Stage I Breast Cancer AJCC v7; Stage I Colorectal Cancer AJCC v6 and v7; Stage I Esophageal Cancer AJCC V7; Stage I Gastric Cancer AJCC V7; Stage I Lung Cancer AJCC v7; Stage I Ovarian Cancer AJCC v6 and v7; Stage I Pancreatic Cancer AJCC v6 and v7; Stage I Prostate Cancer AJCC v7; Stage I Uterine Corpus Cancer AJCC v7; Stage II Bladder Cancer AJCC v6 and v7; Stage II Breast Cancer AJCC v6 and v7; Stage II Colorectal Cancer AJCC v7; Stage II Esophageal Cancer AJCC v7; Stage II Gastric Cancer AJCC v7; Stage II Lung Cancer AJCC v7; Stage II Ovarian Cancer AJCC v6 and v7; Stage II Pancreatic Cancer AJCC v6 and v7; Stage II Prostate Cancer AJCC v7; Stage II Uterine Corpus Cancer AJCC v7; Stage III Bladder Cancer AJCC v6 and v7; Stage III Breast Cancer AJCC v7; Stage III Colorectal Cancer AJCC v7; Stage III Esophageal Cancer AJCC v7; Stage III Gastric Cancer AJCC v7; Stage III Lung Cancer AJCC v7; Stage III Ovarian Cancer AJCC v6 and v7; Stage III Pancreatic Cancer AJCC v6 and v7; Stage III Prostate Cancer AJCC v7; Stage III Uterine Corpus Cancer AJCC v7; Stage IV Bladder Cancer AJCC v7; Stage IV Breast Cancer AJCC v6 and v7; Stage IV Colorectal Cancer AJCC v7; Stage IV Esophageal Cancer AJCC v7; Stage IV Gastric Cancer AJCC v7; Stage IV Lung Cancer AJCC v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Pancreatic Cancer AJCC v6 and v7; Stage IV Prostate Cancer AJCC v7; Stage IV Uterine Corpus Cancer AJCC v7; Thyroid Gland Carcinoma
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Participants with a cancer diagnosis: Documentation of disease:
- Histologic documentation: Histologically confirmed diagnosis of invasive cancer
- Stage: Stage I-IV per American Joint Committee on Cancer (AJCC) 7th edition, with the exception of patients with leukemia, lymphoma, and multiple myeloma
- For leukemia: Type (chronic lymphocytic leukemia [CLL], chronic myeloid leukemia [CML], acute lymphoblastic lymphoma [ALL], acute myeloid leukemia [AML])
- For lymphoma: Stage I-IV based on Ann Arbor staging
- For multiple myeloma: Stage I, II, III based on Revised International Staging System (RISS)
- One of the following tumor types:
- Colorectal
- Bladder
- Head and neck
- Hepatobiliary
- Lung
- Lymphoma
- Leukemia
- Ovary *** For these specific cancer types only, patients may be enrolled prior to histologic confirmation of malignancy. Sites are required to contact the study chairs to review appropriateness for enrollment
- Pancreas *** For these specific cancer types only, patients may be enrolled prior to histologic confirmation of malignancy. Sites are required to contact the study chairs to review appropriateness for enrollment
- Multiple myeloma
- Gastric, esophageal or gastroesophageal
- Breast
- Thyroid
- Kidney
- For these specific cancer types only, patients may be enrolled prior to histologic confirmation of malignancy. Sites are required to contact the study chairs to review appropriateness for enrollment
- Endometrium
- Prostate
- Melanoma
*** For these specific cancer types only, patients may be enrolled prior to histologic confirmation of malignancy. Sites are required to contact the study chairs to review appropriateness for enrollment
- Sarcoma
- Participants with a cancer diagnosis: No prior definitive systemic or local anti-cancer intervention
- Participants with a cancer diagnosis: Age >= 40 and =\< 75
- Participants with a cancer diagnosis: No known current pregnancy by self-report
- Participants with a cancer diagnosis: No known or prior history of in situ or invasive malignancy (excluding in situ non-melanoma skin cancers) other than the current cancer diagnosis
- Participants with a cancer diagnosis: Willingness to provide blood samples for research use
- Participants with a cancer diagnosis: Absence of medical contraindications to a research blood draw volume of 60 mL
- Participants with a cancer diagnosis: No history of organ transplantation
- Participants with a cancer diagnosis: Ability to read and comprehend English or Spanish
- Eligibility is restricted to individuals who can comprehend and read English or Spanish given that participation in the study will require the ability to read and complete questionnaires that are available only in those two languages
- Participants without a cancer diagnosis and without suspicion of cancer: Age >= 40 and =\< 75
- Participants without a cancer diagnosis and without suspicion of cancer: No known current pregnancy by self-report
- Participants without a cancer diagnosis and without suspicion of cancer: No known or prior history of in situ or invasive malignancy (excluding in situ non-melanoma skin cancers)
- Participants without a cancer diagnosis and without suspicion of cancer: Willingness to provide blood samples for research use
- Participants without a cancer diagnosis and without suspicion of cancer: Absence of medical contraindications to a research blood draw volume of 60 mL
- Participants without a cancer diagnosis and without suspicion of cancer: No history of organ transplantation
- Participants without a cancer diagnosis and without suspicion of cancer: Ability to read and comprehend English or Spanish
- Eligibility is restricted to individuals who can comprehend and read English or Spanish given that participation in the study will require the ability to read and complete questionnaires that are available only in those two languages
- Participants with a high suspicion of cancer: High suspicion of ovarian cancer, pancreatic cancer, kidney cancer, or melanoma by clinical and/or radiological assessment, with plans for histologic or cytologic confirmation within 28 days after study blood draw
- Examples of highly suspicious cases include: elevated CA125 and abnormal transvaginal ultrasound, suspicious renal or pancreatic mass on imaging, suspicious cutaneous lesion concerning for melanoma
- Participants with a high suspicion of cancer: Central review of radiology reports and/or clinical documentation conducted by study chairs
- Participants with a high suspicion of cancer: Age >= 40 and =\< 75
- Participants with a high suspicion of cancer: No known current pregnancy by self-report
- Participants with a high suspicion of cancer: No known or prior history of in situ or invasive malignancy (excluding in situ non-melanoma skin cancers) other than the current cancer diagnosis
- Participants with a high suspicion of cancer: Willingness to provide blood samples for research use
- Participants with a high suspicion of cancer: Absence of medical contraindications to a research blood draw volume of 60 mL
- Participants with a high suspicion of cancer: No history or organ transplantation
- Participants with a high suspicion of cancer: Ability to read and comprehend English or Spanish * Eligibility is restricted to individuals who can comprehend and read English and Spanish given that participation in the study will require the ability to read and complete questionnaires that are available only in those two languages
Recruiting US locations
Anchorage Associates in Radiation Medicine
Anchorage, AK 98508
Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org
Alaska Breast Care and Surgery LLC
Anchorage, AK 99508
Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Anchorage, AK 99508
Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Anchorage, AK 99508
Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Anchorage, AK 99508
Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Anchorage, AK 99508
Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org
Kingman Regional Medical Center
Kingman, AZ 86401
Site contact: Site Public Contact · 702-384-0013 · research@sncrf.org
Cancer Center at Saint Joseph's
Phoenix, AZ 85004
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Mercy Hospital Fort Smith
Fort Smith, AR 72903
Site contact: Site Public Contact · 800-378-9373
CARTI Cancer Center
Little Rock, AR 72205
Site contact: Site Public Contact · 501-906-4199 · Research@CARTI.com
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, CA 93420
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
PCR Oncology
Arroyo Grande, CA 93420
Site contact: Site Public Contact · 702-384-0013 · research@sncrf.org
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, CA 93301
Site contact: Site Public Contact · 661-323-4673
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, CA 91505
Site contact: Site Public Contact · 818-847-4793 · Najee.Boucher@providence.org
Mercy Cancer Center - Carmichael
Carmichael, CA 95608
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Mercy San Juan Medical Center
Carmichael, CA 95608
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@commonspirit.org
Mercy Cancer Center - Elk Grove
Elk Grove, CA 95758
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Veterans Affairs Loma Linda Healthcare System
Loma Linda, CA 92357
Site contact: Site Public Contact · 800-741-8387
Tibor Rubin VA Medical Center
Long Beach, CA 90822
Site contact: Site Public Contact · 562-826-8000
Contra Costa Regional Medical Center
Martinez, CA 94553-3156
Site contact: Site Public Contact · 925-957-5400
Mercy Cancer Center
Merced, CA 95340
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Providence Queen of The Valley
Napa, CA 94558
Site contact: Site Public Contact · 707-521-3830
Eisenhower Medical Center
Rancho Mirage, CA 92270
Site contact: Site Public Contact · 760-834-3798
Mercy Cancer Center - Rocklin
Rocklin, CA 95765
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Mercy Cancer Center - Sacramento
Sacramento, CA 95816
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, CA 93401
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Mission Hope Medical Oncology - Santa Maria
Santa Maria, CA 93444
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Providence Medical Foundation - Santa Rosa
Santa Rosa, CA 95403
Site contact: Site Public Contact · 707-521-3830
Providence Santa Rosa Memorial Hospital
Santa Rosa, CA 95405
Site contact: Site Public Contact · 707-521-3830
Saint Helena Hospital
St. Helena, CA 94574
Site contact: Site Public Contact · 707-967-3698
Saint Joseph's Medical Center
Stockton, CA 95204
Site contact: Site Public Contact · 209-461-5257
John Muir Medical Center-Walnut Creek
Walnut Creek, CA 94598
Site contact: Site Public Contact · 925-941-4246 · clinicalresearch@johnmuirhealth.com
Woodland Memorial Hospital
Woodland, CA 95695
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Rocky Mountain Regional VA Medical Center
Aurora, CO 80045
Site contact: Site Public Contact · 888-336-8262
UCHealth University of Colorado Hospital
Aurora, CO 80045
Site contact: Site Public Contact · 720-848-0650
Penrose-Saint Francis Healthcare
Colorado Springs, CO 80907
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, CO 80907
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Saint Francis Cancer Center
Colorado Springs, CO 80923
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
AdventHealth Porter
Denver, CO 80210
Site contact: Site Public Contact · research.institute@adventhealth.com
CommonSpirit Cancer Center Mercy
Durango, CO 81301
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Mercy Medical Center
Durango, CO 81301
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Poudre Valley Hospital
Fort Collins, CO 80524
Site contact: Site Public Contact · 970-297-6150
Cancer Care and Hematology-Fort Collins
Fort Collins, CO 80528
Site contact: Site Public Contact · 773-702-9171 · protocols@AllianceNCTN.org
UCHealth Greeley Hospital
Greeley, CO 80631
Site contact: Site Public Contact · 773-702-9171 · protocols@AllianceNCTN.org
CommonSpirit Saint Anthony Hospital Cancer Center
Lakewood, CO 80228
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
AdventHealth Littleton
Littleton, CO 80122
Site contact: Site Public Contact · research.institute@adventhealth.com
Longmont United Hospital
Longmont, CO 80501
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Medical Center of the Rockies
Loveland, CO 80538
Site contact: Site Public Contact · 970-203-7083
AdventHealth Parker
Parker, CO 80138
Site contact: Site Public Contact · research.institute@adventhealth.com
Saint Mary Corwin Medical Center
Pueblo, CO 81004
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
Saint Anthony North Hospital
Westminster, CO 80023
Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org
MedStar Georgetown University Hospital
Washington D.C., DC 20007
Site contact: Site Public Contact · 202-444-2223
MedStar Washington Hospital Center
Washington D.C., DC 20010
Site contact: Site Public Contact · 202-877-8839
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, FL 33180
Site contact: Site Public Contact · 305-674-2625 · yenrique@msmc.com
Schulze Family Foundation Cancer Clinic - Bonita Health Center
Bonita Springs, FL 34135
Site contact: Site Public Contact · 239-343-9660 · RCCR@leehealth.org
Morton Plant Hospital
Clearwater, FL 33756
Site contact: Site Public Contact · 855-314-8646
Broward Health North
Deerfield Beach, FL 33064
Site contact: Site Public Contact · 954-941-8300
Holy Cross Hospital
Fort Lauderdale, FL 33308
Site contact: Site Public Contact · eileen.georgi@holy-cross.com
Broward Health Medical Center
Fort Lauderdale, FL 33316
Site contact: Site Public Contact · 302-651-5572 · Allison.bruce@nemours.org
Regional Cancer Center-Lee Memorial Health System
Fort Myers, FL 33905
Site contact: Site Public Contact · 773-702-9171 · protocols@AllianceNCTN.org
+ 553 more on the official record.
Study contacts (from the official record)
- Marie Wood, MD · (720) 848-0300 · marie.wood@cuanschutz.edu
Similar studies in Alaska
All healthy volunteers studies in Alaska →- RecruitingHealthy volunteers
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
Ecotera Health LLC
- Location
- Anchorage, AK + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
Alliance for Clinical Trials in Oncology
- Location
- Anchorage, AK + 319 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Family Communications After Genetic Testing
Alliance for Clinical Trials in Oncology
- Location
- Anchorage, AK + 347 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
Alliance for Clinical Trials in Oncology
- Location
- Fairbanks, AK + 350 other US sites
- Eligibility basics
- Ages 18+