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Family Communications After Genetic Testing

Alliance for Clinical Trials in Oncology · with National Cancer Institute (NCI) · NCT07143487

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
4186
US sites recruiting
348
Study start
April 6, 2026
Record last updated
October 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer. It is estimated that 30% of cases of colorectal cancer have a genetic basis and about 15% of these patients have a disease-causing (pathogenic) inherited (germline) variant in a cancer susceptibility gene. Most individuals carrying a pathogenic germline variant are unaware of their cancer risk and may not meet guidelines for genetic testing. Identifying pathogenic germline variants or hereditary cancer syndromes in cancer patients has important implications for their at-risk relatives who may not know that they are at high risk for cancer. The burden of communicating this risk to first-degree relatives often falls on the patients, who may lack sufficient knowledge to correctly share and explain their genetic test results. Receiving provider-mediated communication of genetic testing results may be more effective at communicating genetic risk to first-degree relatives than the usual practice of proband-mediated communication.

Being studied: Biospecimen Collection; Genetic Testing; Communication Intervention; Survey Administration

Conditions: Colon Adenocarcinoma; Colorectal Adenocarcinoma; Rectal Adenocarcinoma; Stage I Colon Cancer AJCC v8; Stage I Colorectal Cancer AJCC v8; Stage I Rectal Cancer AJCC v8; Stage II Colon Cancer AJCC v8; Stage II Colorectal Cancer AJCC v8; Stage II Rectal Cancer AJCC v8; Stage III Colon Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Rectal Cancer AJCC v8

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • STEP 1 PROBANDS: Age >= 18 years
  • STEP 1 PROBANDS: Patients with a newly diagnosed (within 3 months of registration), primary colorectal adenocarcinoma, stage I to IV
  • Histologically proven stage I to IV colon or rectal adenocarcinoma (any T or N, M+). Tumors deemed to originate in the colon can extend into/involve the small bowel (e.g., those at the ileocecal valve). Tumors will be regarded as originating in the colon if the entire tumor is in the colon. In the case of rectal involvement, the cancer will be considered a rectal primary
  • Patients with more than one primary colon adenocarcinoma are eligible
  • STEP 1 PROBANDS: No patients with stage 0 or in-situ colorectal cancer
  • STEP 1 PROBANDS: Patients who have had prior malignancies are eligible, including non-invasive cancers
  • STEP 1 PROBANDS: Patients with synchronous second malignancies are eligible
  • STEP 1 PROBANDS: Have not received germline testing in the 2 years prior to enrollment or known hereditary colon cancer syndromes
  • STEP 1 PROBANDS: Patients must have at least 2 living FDRs who meet the eligibility criteria, with whom the patient is willing to share their cancer diagnosis
  • STEP 1 PROBANDS: In order to complete the mandatory patient-completed measures and view the video and receive genetic education and counseling, participants must be able to speak and read English or Spanish
  • STEP 1 PROBANDS: No known diagnosis of dementia or cognitive impairment. Persons with impaired decision-making capacity are ineligible as they need to be able to understand genetic test results, its implications for the patient and family, and explain genetic test results to their family members
  • No persons with a known psychiatric or documented developmental disorder that affects cognitive or emotional functions to the extent that the capacity for judgment and reason is significantly diminished, such that they cannot participate based on the judgment of the treating physician
  • STEP 2 PROBANDS: Probands positive for a pathogenic germline variant (PGV) in a cancer susceptibility gene
  • FDRs: Age >= 18 years
  • FDRs: Have not previously received germline genetic testing or known hereditary colon cancer syndromes
  • FDRs: FDRs must reside within the United States, as genetic testing from LabCorp is only available to United States (U.S.) residents
  • FDRs: In order to complete the mandatory patient-completed measures, participants must be able to speak and read English or Spanish

Exclusion Criteria

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Recruiting US locations

  • Anchorage Associates in Radiation Medicine

    Anchorage, AK 98508

    Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org

  • Alaska Breast Care and Surgery LLC

    Anchorage, AK 99508

    Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org

  • Alaska Oncology and Hematology LLC

    Anchorage, AK 99508

    Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org

  • Alaska Women's Cancer Care

    Anchorage, AK 99508

    Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org

  • Katmai Oncology Group

    Anchorage, AK 99508

    Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org

  • Providence Alaska Medical Center

    Anchorage, AK 99508

    Site contact: Site Public Contact · 907-212-6871 · AKPAMC.OncologyResearchSupport@providence.org

  • Fairbanks Memorial Hospital

    Fairbanks, AK 99701

    Site contact: Site Public Contact · 907-458-3043 · Veronica.Stevenson@foundationhealth.org

  • Cancer Center at Saint Joseph's

    Phoenix, AZ 85004

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Mercy Hospital Fort Smith

    Fort Smith, AR 72903

    Site contact: Site Public Contact · 800-378-9373

  • CARTI Cancer Center

    Little Rock, AR 72205

    Site contact: Site Public Contact · 501-906-4199 · Research@CARTI.com

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, CA 93420

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, CA 91505

    Site contact: Site Public Contact · 818-847-4793 · Najee.Boucher@providence.org

  • Marshall Cancer Center

    Cameron Park, CA 95682

    Site contact: Site Public Contact · 530-672-7050 · cancerservices@marshallmedical.org

  • Mercy Cancer Center - Carmichael

    Carmichael, CA 95608

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Mercy San Juan Medical Center

    Carmichael, CA 95608

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@commonspirit.org

  • Enloe Medical Center

    Chico, CA 95926

    Site contact: Site Public Contact · 530-332-4700

  • Mercy Cancer Center - Elk Grove

    Elk Grove, CA 95758

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Fremont - Rideout Cancer Center

    Marysville, CA 95901

    Site contact: Site Public Contact · 530-749-4400

  • Mercy Cancer Center

    Merced, CA 95340

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Providence Queen of The Valley

    Napa, CA 94558

    Site contact: Site Public Contact · 707-521-3830

  • Mercy Cancer Center - Rocklin

    Rocklin, CA 95765

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Mercy Cancer Center - Sacramento

    Sacramento, CA 95816

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, CA 93401

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Mission Hope Medical Oncology - Santa Maria

    Santa Maria, CA 93444

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Providence Medical Foundation - Santa Rosa

    Santa Rosa, CA 95403

    Site contact: Site Public Contact · 707-521-3830

  • Providence Santa Rosa Memorial Hospital

    Santa Rosa, CA 95405

    Site contact: Site Public Contact · 707-521-3830

  • Saint Helena Hospital

    St. Helena, CA 94574

    Site contact: Site Public Contact · 707-967-3698

  • Saint Joseph's Medical Center

    Stockton, CA 95204

    Site contact: Site Public Contact · 209-461-5257

  • Gene Upshaw Memorial Tahoe Forest Cancer Center

    Truckee, CA 96161

    Site contact: Site Public Contact · 530-582-6450

  • Woodland Memorial Hospital

    Woodland, CA 95695

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Penrose-Saint Francis Healthcare

    Colorado Springs, CO 80907

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, CO 80907

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Saint Francis Cancer Center

    Colorado Springs, CO 80923

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • CommonSpirit Cancer Center Mercy

    Durango, CO 81301

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Mercy Medical Center

    Durango, CO 81301

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • CommonSpirit Saint Anthony Hospital Cancer Center

    Lakewood, CO 80228

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Longmont United Hospital

    Longmont, CO 80501

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Saint Mary Corwin Medical Center

    Pueblo, CO 81004

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Saint Anthony North Hospital

    Westminster, CO 80023

    Site contact: Site Public Contact · 720-874-1881 · ResearchInstituteInquiries@CommonSpirit.org

  • Holy Cross Hospital

    Fort Lauderdale, FL 33308

    Site contact: Site Public Contact · eileen.georgi@holy-cross.com

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, ID 83706

    Site contact: Site Public Contact · 734-712-3671 · stephanie.couch@stjoeshealth.org

  • Saint Luke's Cancer Institute - Boise

    Boise, ID 83712

    Site contact: Site Public Contact · 208-381-2774 · eslinget@slhs.org

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, ID 83605

    Site contact: Site Public Contact · 734-712-3671 · stephanie.couch@stjoeshealth.org

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, ID 83814

    Site contact: Site Public Contact · 406-969-6060 · mccinfo@mtcancer.org

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, ID 83619

    Site contact: Site Public Contact · 208-381-2774 · eslinget@slhs.org

  • Idaho Urologic Institute-Meridian

    Meridian, ID 83642

    Site contact: Site Public Contact · 734-712-3671 · stephanie.couch@stjoeshealth.org

  • Saint Luke's Cancer Institute - Meridian

    Meridian, ID 83642

    Site contact: Site Public Contact · 208-381-2774 · eslinget@slhs.org

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, ID 83687

    Site contact: Site Public Contact · 406-969-6060 · mccinfo@mtcancer.org

  • Saint Luke's Cancer Institute - Nampa

    Nampa, ID 83687

    Site contact: Site Public Contact · 208-381-2774 · eslinget@slhs.org

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, ID 83854

    Site contact: Site Public Contact · 406-969-6060 · mccinfo@mtcancer.org

  • Kootenai Clinic Cancer Services - Sandpoint

    Sandpoint, ID 83864

    Site contact: Site Public Contact · 406-969-6060 · mccinfo@mtcancer.org

  • Saint Luke's Cancer Institute - Twin Falls

    Twin Falls, ID 83301

    Site contact: Site Public Contact · 208-381-2774 · eslinget@slhs.org

  • OSF Saint Anthony's Health Center

    Alton, IL 62002

    Site contact: Site Public Contact · 618-463-5623

  • Advocate Outpatient Center - Aurora

    Aurora, IL 60506

    Site contact: Site Public Contact · ncorp@aah.org

  • Advocate Good Shepherd Hospital

    Barrington, IL 60010

    Site contact: Site Public Contact · 847-842-4847

  • Illinois CancerCare-Bloomington

    Bloomington, IL 61704

    Site contact: Site Public Contact · 309-243-3605 · andersonj@illinoiscancercare.com

  • Illinois CancerCare-Canton

    Canton, IL 61520

    Site contact: Site Public Contact · 309-243-3605 · andersonj@illinoiscancercare.com

  • Memorial Hospital of Carbondale

    Carbondale, IL 62902

    Site contact: Site Public Contact · 618-457-5200 · clinical.research@sih.net

  • SIH Cancer Institute

    Carterville, IL 62918

    Site contact: Site Public Contact · 618-985-3333 · clinical.research@sih.net

  • Illinois CancerCare-Carthage

    Carthage, IL 62321

    Site contact: Site Public Contact · 309-243-3605 · andersonj@illinoiscancercare.com

+ 288 more on the official record.

Study contacts (from the official record)

  • Rachel Wills · 773-702-9814 · rwills@bsd.uchicago.edu
All healthy volunteers studies in Alaska →
Family Communications After Genetic Testing (NCT07143487) | Bored Studies