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RecruitingAccepts healthy volunteersPhase 1

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

University of California, San Francisco · with National Institute on Drug Abuse (NIDA) · NCT05962229

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
18
US sites recruiting
1
Study start
December 6, 2024
Record last updated
May 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

Being studied: (S)-Nicotine; (R)- nicotine; Racemic nicotine

Conditions: Nicotine Dependence; Nicotine Vaping

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy on the basis of medical history and limited physical examination.
  • Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)

Exclusion Criteria

  • • Medications
  • Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
  • Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
  • Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
  • Any stimulant medications (example: Adderall) generally given for ADHD treatment.
  • Pregnancy
  • Pregnancy (self-reported and urine pregnancy test)
  • Breastfeeding (determined by self-report)
  • Women of childbearing potential must be using an acceptable method of contraception
  • Inability to read and write in English
  • A known propylene glycol/vegetable glycerin allergy
  • Uncomfortable with getting blood drawn

Recruiting US locations

  • Zuckerberg San Francisco General Hospital (ZSFG)

    San Francisco, CA 94110

    Site contact: Lisa Lawrence · 415-502-2465 · lisa.lawrence@ucsf.edu

Study contacts (from the official record)

  • Lisa Lawrence · 628-206-4204 · lisa.lawrence@ucsf.edu
  • Armando Barraza · 510-560-4842 · armando.barraza@ucsf.edu
All smoking & vaping studies in California →
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic… (NCT05962229) | Bored Studies