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Using Nicotine to Reverse Age-related Auditory Processing Deficits

University of California, Irvine · with National Institute on Aging (NIA) · NCT04971954

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
48
US sites recruiting
2
Study start
February 1, 2022
Record last updated
October 19, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.

Being studied: Nicotine gum; Placebo gum

Conditions: Auditory Perceptual Impairment; Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • between 18 and 85 years of age
  • non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency
  • cognitive performance within two standard deviations of the CERAD mean

Exclusion Criteria

  • less than 18 or greater than 85 years of age
  • deafness or excessive hearing loss
  • smokers with a score between 3 and 10 on the Fagerström index of smoking dependency
  • history of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease
  • regular use of prescription medications (excluding oral contraceptives)
  • drug dependency

Recruiting US locations

  • Hearing and Speech Lab

    Irvine, CA 92697

    Site contact: Fan-Gang Zeng · 9498249107 · fzeng@uci.edu

  • San Diego State University

    San Diego, CA 92182

    Site contact: Xianhui (Kaye) Wang, PhD · 619-594-7746 · kwang5@sdsu.edu

Study contacts (from the official record)

  • Fan-Gang Zeng · 9498249107 · fzeng@uci.edu
All smoking & vaping studies in California →
Using Nicotine to Reverse Age-related Auditory Processing Deficits (NCT04971954) | Bored Studies