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RecruitingAccepts healthy volunteersPhase 2

Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)

Stanford University · with National Institute of Mental Health (NIMH) · NCT05940324

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
150
US sites recruiting
1
Study start
February 24, 2024
Record last updated
April 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.

Being studied: Ketamine; Naltrexone Pill; Placebo pill

Conditions: Obsessive-Compulsive Disorder

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Eligibility Criteria for Participants with OCD:

Inclusion Criteria

  • Ages 18-65
  • Meet the criteria for OCD diagnosis
  • Failed at least 1 prior trial of standard first-line OCD treatment
  • Agree to the following lifestyle modifications: comply with requirements for fasting prior to the Experimental Session, not enroll in any other interventional clinical trials during the duration of the study, and commit to medication study procedures.
  • Able to provide informed consent

Exclusion Criteria

  • prior naltrexone or ketamine use/exposure
  • Any current or past medical/psychiatric condition that makes participation unsafe in the opinion of the investigator or study physician
  • Pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control
  • the presence of metal in the body that is contraindicated for MRI scans

Eligibility Criteria for Healthy Volunteers:

Inclusion Criteria

  • Ages 18-65
  • Able to provide informed consent

Exclusion Criteria

  • current or past use of psychotropic medication
  • pregnant or nursing females
  • the presence of metal in the body that is contraindicated for MRI scans

Recruiting US locations

  • Department of Psychiatry & Behavioral Sciences

    Stanford, CA 94305

    Site contact: OCD Research · 650-723-4095

Study contacts (from the official record)

  • Pavithra Mukunda, MS · 6504972578 · ocdresearch@stanford.edu
  • Carolyn I Rodriguez, MD, PhD · (650) 723-6158 · ocdresearch@stanford.edu
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Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD… (NCT05940324) | Bored Studies