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Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

University of California, San Francisco · with United States Department of Defense · NCT04722835

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40–75 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
40
US sites recruiting
1
Study start
March 1, 2021
Record last updated
June 4, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design suitable preventative and therapeutic strategies for its management. This Department of Defense (DOD) discovery research proposes to develop methodologies and generate preliminary data needed to lay the foundation for a large study that would investigate the underlying biological susceptibility of those who smoke tobacco to develop COPD.

Being studied: Bronchoscopy with Bronchoalveolar Lavage (BAL)

Conditions: Copd; Smoking; Tobacco Use

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Ages between 40 to 75 years old.
  • History of at least 20 pack-years of smoking.
  • No diagnosis of COPD or asthma.
  • No spirometric evidence of airflow obstruction as determined by FEV1/FVC ratio ≥0.7.
  • FEV1 and FVC >lower limit of normal.
  • Less than 1 pack-year history of tobacco smoking and no tobacco use within the past 12 months.
  • Subjects will be divided into two groups by their RV/TLC:

Normal RV/TLC Group

  • Plethysmographic RV/TLC equal or less than lower limit of normal.

Abnormal RV/TLC Group

  • Plethysmographic RV/TLC higher than lower limit of normal.

Exclusion Criteria

  • Any history of IV drug use or inhalation of recreational drugs other than marijuana: A- within the past 20 years. B- more than 100 times IV drug usage. C- longer than 1 year usage.
  • Marijuana use >400 joints in lifetime or any within past 6 months.
  • Inability to walk briskly, run on treadmill, or pedal on ergometer to perform the study-required exercise level.
  • Pregnant/breast feeding.
  • Serious and active heart conditions- defined by stable or unstable angina, recent myocardial infarction (within the last 2 years), active congestive heart failure, ischemic cardiomyopathy.
  • Liver cirrhosis.
  • History of chronic active Hepatitis B or C.

Recruiting US locations

  • San Francisco VA Medical Center

    San Francisco, CA 94121

    Site contact: Yorusaliem Abrham · 415-221-4810 · yorusaliem.abrham@ucsf.edu

Study contacts (from the official record)

  • Yorusaliem Abrham · 415-221-4810 · yorusaliem.abrham@ucsf.edu
  • Helen Lozier, B.A. · (415) 609-6738 · helen.lozier@ucsf.edu
All smoking & vaping studies in California →
Lung Macrophage Populations and Functions in Chronic Obstructive… (NCT04722835) | Bored Studies