Measuring Environmental Tobacco and Cannabis: Pollutants and Exposures

Inclusion Criteria

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Adult nonsmokers, aged 21-50, who:

• Are healthy on the basis of medical history
• Have systolic blood pressure \<150
• Have diastolic blood pressure \<100
• Have BMI between 18.1 and 34.9
• Able to perform moderate exercise,
• Are not exposed to tobacco or cannabis SHS in their daily lives. (Nonsmoking status and low SHS exposure are determined by self-report on the screening questionnaire, salivary cotinine \< 10 ng/ml and THC \< 50 ng/m and exhaled CO2 below 4 ppm)

Exclusion Criteria

• Current use of cannabis products, including CBD and edible THC products
• Regular exposure to secondhand tobacco or cannabis smoke
• Positive SARS-CoV-2 antibody test
• Age 18 \< or > 50
• Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma.
• Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications
• Systolic blood pressure > 150
• Diastolic blood pressure > 100
• Pregnancy or breastfeeding (by urine hCG and/or history)
• Alcohol or illicit drug dependence within the past 5 years
• BMI > 35 and \< 18
• Current illicit drug use (by history or urine test)
• More than 1 pack year smoking history
• Ever a daily marijuana smoker
• Smoked anything within the last 2 months
• Occupational exposure to smoke, dusts OR fumes
• Concurrent participation in another clinical trial
• Unable to communicate in English
• No social security number