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Neuroimaging of Opioid Phase (OPAL)

Duke University · with National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA) · NCT05905419

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
140
US sites recruiting
1
Study start
June 1, 2023
Record last updated
June 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.

Being studied: Opioid Phase

Conditions: Chronic Pain; Opioid Use

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria for Healthy Controls

  • female and ages 18+
  • ability to read/understand English and give consent to participate
  • no current or history of chronic pain
  • not regularly taking any pain-relieving or mood-altering medications (per PI discretion)
  • absence of use of opioid medications

Inclusion Criteria for Individuals with Chronic Pain:

  • female and ages 18 +
  • ability to read/understand English and give consent to participate
  • self-reported or physician diagnosis of fibromyalgia and/or chronic pain
  • current use of opioid medication(s) for inclusion in the opioid patient group -OR- absence of use of opioid medications for inclusion in the non-opioid patient group

Exclusion Criteria (for both groups):

  • limited ability to participate fully in behavioral tasks, longitudinal follow-up
  • MRI contraindication
  • any factors that at the discretion of the investigators would adversely affect the participant or the integrity of the study
  • male

Recruiting US locations

  • Duke University Medical Center

    Durham, NC 27710

    Site contact: HAPN Lab Manager · 919-684-2758 · ChronicPainResearch@duke.edu

Study contacts (from the official record)

  • HAPN Lab Manager · 919-684-2758 · chronicpainresearch@duke.edu
  • Angelina Xiong, BS · 919-684-3136 · angelina.xiong@duke.edu
All pain studies in North Carolina →
Neuroimaging of Opioid Phase (OPAL) (NCT05905419) | Bored Studies