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Neurophysiologic Biomarkers for Cognitive Rehabilitation

VA Office of Research and Development · NCT05945602

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
80
US sites recruiting
1
Study start
October 1, 2023
Record last updated
October 9, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Cognitive symptoms of schizophrenia interfere with daily life-from managing self-care, to more complex tasks like taking medications and living independently. Unfortunately, these cognitive symptoms are not corrected by 'standard of care' treatments (antipsychotic medications), although some schizophrenia patients may experience modest clinical and cognitive benefits from cognitive remediation. To enhance the clinical impact of cognitive remediation and other rehabilitative interventions for Veterans living with chronic psychosis, this study will develop novel brain-based tools to help identify those Veterans who are most likely to benefit from pro-cognitive therapies. These studies may advance predictive algorithms that improve functional outcomes and life quality in Veterans with schizophrenia.

Being studied: Neurophysiologic Biomarker Assessments

Conditions: Schizophrenia Spectrum Disorders

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Have a DSM-5 diagnosis of a chronic psychotic disorder (e.g., schizophrenia, schizoaffective disorder, or delusional disorder); or b) are in good general mental and physical health (i.e., no active mental health condition).
  • Fluent in spoken and written English.
  • No impairment in hearing or vision.

Exclusion Criteria

  • Active substance other than cannabis within the last 30 days as determined by self-report or positive urine toxicology (obtained as part of the screening process).
  • History of significant medical or neurological illness or intellectual disability.
  • Inability to comprehend or provide informed consent.
  • Specific to healthy comparison subjects: past or present diagnosis of schizophrenia, schizoaffective disorder, or other chronic psychotic disorder.

Recruiting US locations

  • VA San Diego Healthcare System, San Diego, CA

    San Diego, CA 92161-0002

    Site contact: Juan Molina, MD · (202) 555-8975 · Juan.Molina@va.gov

Study contacts (from the official record)

  • Juan Molina, MD · (202) 555-8975 · Juan.Molina@va.gov
All mental health studies in California →
Neurophysiologic Biomarkers for Cognitive Rehabilitation (NCT05945602) | Bored Studies