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Sleep TMS for Depression

Stanford University · with National Center for Advancing Translational Sciences (NCATS), National Institute of Mental Health (NIMH) · NCT06824415

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
55
US sites recruiting
1
Study start
May 1, 2025
Record last updated
June 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.

Being studied: TMS

Conditions: Major Depression; Sleep

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults ages 18-65 years
  • Current Major Depressive Disorder (MDD) diagnosis
  • Failed ≥1 antidepressant medication
  • Moderate-to-severe depression
  • Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
  • Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.

Exclusion Criteria

  • Intellectual disability
  • Significant head injury/neurological disorder
  • Pregnancy or postpartum
  • TMS/MRI contraindications
  • Active substance use/suicidal ideation

Recruiting US locations

  • Stanford University

    Stanford, CA 94305

    Site contact: Hansong Lee, MS · 408-909-2203 · kellerlab@stanford.edu

Study contacts (from the official record)

  • Hansong Lee, MS · 408-909-2203 · kellerlab@stanford.edu
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Sleep TMS for Depression (NCT06824415) | Bored Studies