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RecruitingAccepts healthy volunteersPhase 4

Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

University of North Carolina, Chapel Hill · with National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS) · NCT06841913

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–49 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
112
US sites recruiting
1
Study start
September 26, 2025
Record last updated
April 30, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study will investigate the effects of woodsmoke (WS) exposure on human nasal mucosal immune responses to viral infection. The study tests the hypotheses that WS exposure modifies biomarkers of nasal mucosal immune function, increases in Live Attenuated Influenza Virus (LAIV) -induced nasal symptoms, and reduces mucosal antibody production.

Being studied: LAIV nasal vaccine is chosen as a model viral infection; Wood smoke; Placebo for LAIV nasal vaccine is chosen as a model viral infection; Placebo for Wood Smoke (clean Air Exposure)

Conditions: Smoke Exposure; Influenza

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Normal lung function,
  • oxygen saturation of >94%,
  • normal blood pressure,
  • no respiratory symptoms on history, no abnormalities on exam, normal pulmonary function testing,
  • 18-49 Years of age.

Exclusion Criteria

  • A history of significant chronic illnesses (to include diabetes, autoimmune diseases, immunodeficiency state, known ischemic heart disease, chronic respiratory diseases such as chronic obstructive pulmonary disease or asthma, hypertension)
  • Positive pregnancy test within 48 hours of the time of challenge
  • Use of any inhaled substance (for medical or recreational purposes).
  • Nonsmokers must have been abstinent from smoking for the prior 12 months, having not smoked more than 1 pack over the course of the previous year.
  • History of allergy to eggs
  • Acute, non-chronic, medical conditions, including (but not limited to) pneumonia or bronchitis requiring antibiotics, febrile illnesses, flu-like symptoms must be totally resolved symptomatically for 3 weeks
  • Unspecified illnesses, which in the judgment of the investigator increase the risk associated with the experimental LAIV infection, will be a basis for exclusion.
  • Expected exposure of subject to immunocompromised individuals (who can be infected by LAIV) for the 3 weeks following LAIV inoculation.
  • Use of immunosuppressive drugs within the past 6 months.
  • Previous Woodsmoke exposure \<3 weeks, which is considered to an appropriate washout period

Recruiting US locations

Study contacts (from the official record)

  • Carole Robinette, MS · 919 966-5638 · carole_robinette@med.unc.edu
  • Chris Brooks · chris_brooks@med.unc.edu
All smoking & vaping studies in North Carolina →
Woodsmoke Exposure, Influenza Infection, and Nasal Immunity (NCT06841913) | Bored Studies