Location · Knoxville, TN
Clinical trials in Knoxville, TN
57 recruiting studies have a site in Knoxville, and 12 of them accept healthy volunteers.
57 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- Recruiting
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
Tempus AI
- Location
- Knoxville, TN + 39 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE
Tissium
- Location
- Knoxville, TN + 7 other US sites
- Eligibility basics
- Ages 22+
- RecruitingPhase 3
A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
Eli Lilly and Company
- Location
- Knoxville, TN + 68 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
Alleviant ALLAY-HFrEF Study
Alleviant Medical, Inc.
- Location
- Knoxville, TN + 38 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Calico Life Sciences LLC
- Location
- Knoxville, TN + 33 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 3
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
GlaxoSmithKline
- Location
- Knoxville, TN + 50 other US sites
- Eligibility basics
- Ages 40–80
- RecruitingPhase 3
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
Amgen
- Location
- Knoxville, TN + 69 other US sites
- Eligibility basics
- Ages 18–99
- RecruitingPhase 2
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Celgene
- Location
- Knoxville, TN + 13 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 3
A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN)
Biogen
- Location
- Knoxville, TN + 14 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 3
Efficacy of PP-01 in Mitigating Cannabis Withdrawal Symptoms in Adults With Cannabis Use Disorder
PleoPharma, Inc.
- Location
- Knoxville, TN + 21 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 4
Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants
Neurotech Pharmaceuticals
- Location
- Knoxville, TN + 15 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)
GlaxoSmithKline
- Location
- Knoxville, TN + 93 other US sites
- Eligibility basics
- Ages 18–80
- Recruiting
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
Pulmonx Corporation
- Location
- Knoxville, TN + 17 other US sites
- Eligibility basics
- Ages 40–80
- RecruitingPhase 3
Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design
Axsome Therapeutics, Inc.
- Location
- Knoxville, TN + 48 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Novartis Pharmaceuticals
- Location
- Knoxville, TN + 42 other US sites
- Eligibility basics
- Ages 40–70
- Recruiting
Alleviant ALLAY-HF Study
Alleviant Medical, Inc.
- Location
- Knoxville, TN + 42 other US sites
- Eligibility basics
- Ages 40+
- RecruitingPhase 2
A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis
GlaxoSmithKline
- Location
- Knoxville, TN + 29 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 2/Phase 3
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
EyeBiotech Ltd.
- Location
- Knoxville, TN + 51 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 3
eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation
GlaxoSmithKline
- Location
- Knoxville, TN + 37 other US sites
- Eligibility basics
- Ages 40–75
- Recruiting
Treating Pulmonary Embolism With Laguna Thrombectomy System (TRUST)
Innova Vascular, Inc.
- Location
- Knoxville, TN + 12 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 3
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
United Therapeutics
- Location
- Knoxville, TN + 73 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine
Pfizer
- Location
- Knoxville, TN + 30 other US sites
- Eligibility basics
- Ages 18–45 · Women only
- Recruiting
Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants
Diality Inc.
- Location
- Knoxville, TN + 4 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
MBX Biosciences
- Location
- Knoxville, TN + 3 other US sites
- Eligibility basics
- Ages 18–65