A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
EyeBiotech Ltd. · NCT07496567
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 50+ · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Phase 2, Phase 3
- Target enrollment
- 960
- US sites recruiting
- 52
- Study start
- April 15, 2026
- Record last updated
- August 6, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD).
Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD.
The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Being studied: Tiespectus; Aflibercept
Conditions: Macular Degeneration; Age-Related Macular Degeneration; Choroidal Neovascularization; Wet Macular Degeneration
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
The main inclusion criteria include but are not limited to the following:
- Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
- The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment
The main exclusion criteria include but are not limited to the following
- Has uncontrolled blood pressure at screening
- History of any prior macular laser photocoagulation in the study eye
- History of uveitis in either eye
- History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
- Has uncontrolled glaucoma in the study eye
- Active retinal disease other than the condition under investigation in the study eye
- Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye
Recruiting US locations
Associated Retina Consultants - Gilbert
Gilbert, AZ 85259
Site contact: Study Coordinator · 602-242-4928
The Retina Partners
Encino, CA 91436
Site contact: Jesus Vargas · 818-788-9333 · jesusv@theretinapartners.com
Northern California Retina Vitreous Associates Medical Group, Inc.
Mountain View, CA 94040
Site contact: Study Coordinator · 650-963-3465
Orange County Retina Medical Group
Santa Ana, CA 92705
Site contact: Study Coordinator · 714-972-8432
Retina Consultants of Southern Colorado
Colorado Springs, CO 80909
Site contact: Study Coordinator · 719-473-9595
RSC Research LLC
Denver, CO 80222
Site contact: Study Coordinator · 720-443-2425
Retina Consultants of Southern Colorado
Pueblo, CO 81008
Site contact: Study Coordinator · 719-473-9595
Connecticut Eye Consultants, P.C.
Danbury, CT 06810
Site contact: Study Coordinator · 203-791-2020
Retina Consultants, P.C.
Manchester, CT 06042
Site contact: Study Coordinator · 860-646-7704
Retina Group of New England
Waterford, CT 06385
Site contact: Study Coordinator · 860-444-1292
Retina Group of Florida
Fort Myers, FL 33912
Site contact: Study Coordinator · 239-938-1284
Florida Retina Institute
Orlando, FL 32806
Site contact: Study Coordinator · 407-849-9621
Retina Group of Florida (Site 065)
Sarasota, FL 34232
Site contact: Study Coordinator · 941-924-0303
Center for Retina and Macular Disease (Site 062)
Winter Haven, FL 33880
Site contact: Study Coordinator · 863-297-5400
Illinois Retina Associates
Joliet, IL 60435
Site contact: Study Coordinator · 815-744-7515
University Retina & Macula Associates, P.C.
Lemont, IL 60439
Site contact: Study Coordinator · 708-765-4110
Wolfe Eye Clinic
West Des Moines, IA 50266
Site contact: Study Coordinator · 515-223-8686
Retina Associates, LLC
Lenexa, KS 66215
Site contact: Study Coordinator · 913-831-7400
Butchertown Clinical Trials
Louisville, KY 40206
Site contact: Study Coordinator · 502-589-1500
Maine Eye Center (Site 097)
Portland, ME 04101
Site contact: Study Coordinator · 207-523-5548
Mid Atlantic Retina Specialists
Hagerstown, MD 21740
Site contact: Study Coordinator · 301-671-2400
Retina Research Institute at New England Retina Consultants, PC
Springfield, MA 01107
Site contact: Study Coordinator · 413-732-2333
Retina Consultants of Minnesota
Edina, MN 55435
Site contact: Study Coordinator · 952-259-6262
Envision Ocular, LLC
Bloomfield, NJ 07003
Site contact: Study Coordinator · 973-707-5632
Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY
Great Neck, NY 11021
Site contact: Study Coordinator · 516-466-0390
Retina Associates of Western NY, PC (Site 051)
Rochester, NY 14620
Site contact: Study Coordinator · 585-450-2082
Asheville Eye Associates, Retina Division (Site 077)
Asheville, NC 28803
Site contact: Study Coordinator · 828-255-8008
NC Retina
Cary, NC 27511
Site contact: Amanda Smith · 919-782-8038 · asmith@ncretina.com
Graystone Eye
Hickory, NC 28602
Site contact: Study Coordinator · 828-304-6643
NC Retina Associates
Wake Forest, NC 27587
Site contact: Amanda Smith · 919-782-8038 · asmith@ncretina.com
Retina Consultants, LLC
Salem, OR 97302
Site contact: Study Coordinator · 503-371-4350
Cascade Medical Research Institute, LLC
Springfield, OR 97477
Site contact: Study Coordinator · 541-687-1927
Erie Retina Research
Erie, PA 16505
Site contact: Study Coordinator · 814-200-9152
Charleston Neuroscience Institute (Site 034)
Beaufort, SC 29902
Site contact: Study Coordinator · 843-763-4466
Palmetto Retina Center
Florence, SC 29501
Site contact: Study Coordinator · 803-931-0077
Charleston Neuroscience Institute
Ladson, SC 29456
Site contact: Study Coordinator · 843-763-4466
Palmetto Retina Center
West Columbia, SC 29169
Site contact: Study Coordinator · 803-744-0158
Southeastern Retina Associates
Hixson, TN 37343
Site contact: KaSandra "Kassy" Schratter · 423-756-1002 · kschratter@seretina.com
Southeastern Retina Associates (Site 095)
Johnson City, TN 37604
Site contact: Study Coordinator · 423-578-4364
Southeastern Retina Associates, P.C.
Knoxville, TN 37922
Site contact: Study Coordinator · 865-588-0811
Tennessee Retina
Nashville, TN 37203
Site contact: Study Coordinator · 615-983-6000
Retina Consultants of Texas
Bellaire, TX 77401
Site contact: Study Coordinator · 713-394-7576
Texas Retina Associates
Fort Worth, TX 76104
Site contact: Study Coordinator · 817-334-0882
Retina Consultants of Texas
Katy, TX 77494
Site contact: Study Coordinator · 713-524-3434
Austin Retina Associates
Round Rock, TX 78681
Site contact: Study Coordinator · 800-252-8259
Retina Consultants of Texas
San Antonio, TX 78240
Site contact: Study Coordinator · 210-903-1046
Austin Retina Associates
San Marcos, TX 78666
Site contact: Study Coordinator · 512-451-0103
Retina Consultants of Texas
Schertz, TX 78154
Site contact: Study Coordinator · 210-693-1063
Salt Lake Retina
West Jordan, UT 84088
Site contact: Study Coordinator · 801-679-4173
Vistar Eye Center (Site 129)
Roanoke, VA 24019
Site contact: Study Coordinator · 540-342-3400
Pacific Northwest Retina
Bellevue, WA 98004
Site contact: Study Coordinator · 206-215-3850
Northeast Wisconsin Retina Associates
Appleton, WI 54914
Site contact: Study Coordinator · 920-751-8666
Study contacts (from the official record)
- Toll Free Number · 1-888-577-8839 · Trialsites@msd.com