ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Calico Life Sciences LLC · NCT06902558
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18–55 · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Phase 2
- Target enrollment
- 240
- US sites recruiting
- 34
- Study start
- June 9, 2025
- Record last updated
- October 6, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of ADPKD in adult participants.
ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD. Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to placebo. Around 240 adult participants with ADPKD will be enrolled at approximately 100 sites worldwide.
Participants will receive IntraVenous ABBV-CLS-628 or placebo every 4 weeks for 92 weeks. Participants will be followed for up to 15 weeks.
There may be higher treatment burden for participants in this trial compared to their standard of care . Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Being studied: ABBV-CLS-628; Placebo
Conditions: Autosomal Dominant Polycystic Kidney Disease
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Autosomal Dominant Polycystic Kidney Disease (ADPKD) Class 1C, 1D, or 1E based on the Mayo Clinic Imaging Classification of ADPKD.
- Estimated glomerular filtration rate (eGFR) >= 30 mL/min/1.73 m\^2 and \< 90 mL/min/1.73 m\^2, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at Screening.
Exclusion Criteria
- Current interventions to treat ADPKD such as non-approved medications or lifestyle modifications.
- Any exclusionary medical diseases, disorders, or conditions as described in the protocol.
Recruiting US locations
University of Alabama at Birmingham
Birmingham, AL 35294
Site contact: Maria El Hachem · 205-975-0549 · mehachem@uabmc.edu
Valiance Clinical Research - Huntington Park
Huntington Park, CA 90255
Site contact: Josh Lai · 323-484-0508 · j.lai@ValianceClinicalResearch.com
Academic Medical Research Institute (AMRI) - Los Angeles
Los Angeles, CA 90022
Site contact: Mohamed Shahawy, MD, MPH · 323-725-0051 · md@amrionline.net
UC Irvine Medical Center
Orange, CA 92868-3201
Site contact: Ahmad Walid Roshan · 714-509-6271 · ahmadwar@hs.uci.edu
National Institute of Clinical Research - Pomona
Pomona, CA 91768
Site contact: National Institute of Clinical Research, Inc. · 323-725-0657 · nicr@nicresearch.com
University Of California, San Francisco
San Francisco, CA 94143-2202
Site contact: Meyeon Park, MD · 415-514-1122 · PKD@ucsf.edu
Yale University School of Medicine
New Haven, CT 06510
Site contact: Jessica Li · 203-737-1091 · jessica.a.li@yale.edu
South Florida Research Institute
Fort Lauderdale, FL 33313
Site contact: Marie Pierre Louis · 954-739-4474 · marie.pierrelouis@sfriresearch.com
Nature Coast Clinical Research - Inverness
Inverness, FL 34452-4717
Site contact: Rafik Abadier · 352-341-2100 · rabadier@flourishresearch.com
Mayo Clinic Hospital Jacksonville
Jacksonville, FL 32224
Site contact: Mia Schell · 904-953-3671 · schell.mia@mayo.edu
Panax Clinical Research
Miami, FL 33014
Site contact: Robert G. Perry, MD · 305-698-4500 · rperry@panaxcr.com
University of Miami Don Suffer Clinical Research Building
Miami, FL 33136
Site contact: Carlos Bidot · 305-243-8793 · cbidot2@med.miami.edu
Infigo Clinical Research
Sanford, FL 32771
Site contact: Leianna Lewis · info@infigoresearch.com
Emory University School Of Medicine - Atlanta
Atlanta, GA 30322
Site contact: Frederic Rahbari Oskoui · 404-727-2590 · frahbar@emory.edu
CARE-Boise Kidney
Boise, ID 83706
Site contact: Samantha Stinemetz · 208-996-1944 · Samantha@CardioRenalInstitute.com
CARE Institute - Idaho Falls
Idaho Falls, ID 83404
Site contact: Carolina Saldana · 208-984-2273 · Carolina@cardiorenalinstitute.com
Northwestern University Feinberg School of Medicine
Chicago, IL 60611-2927
Site contact: Patrick Fox · 312-503-1887 · patrick.fox@northwestern.edu
University of Iowa
Iowa City, IA 52242
Site contact: Jissele Verdinez · 319-384-5369 · jissele-verdinez@uiowa.edu
University of Kansas Medical Center
Kansas City, KS 66160
Site contact: Jordan Elliott · jelliott11@kumc.edu
Tufts Medical Center
Boston, MA 02111-1552
Site contact: Olaniyi Ogunbodede · 617-636-5076 · olaniyi.ogunbodede@tuftsmedicine.org
Beth Israel Deaconess Medical Center
Boston, MA 02215
Site contact: Peter Czarnecki, MD · 617-632-9890 · nephrologyadminsupport@bidmc.harvard.edu
University Of Michigan
Ann Arbor, MI 48109-5000
Site contact: Michael Heung, MD · 734-936-6489 · mheung@umich.edu
St. Clair Nephrology
Shelby, MI 48315
Site contact: Rosemarie Henschel, RN · 313-432-6273 · rhenschel@scsp.net
Mayo Clinic Hospital - Rochester
Rochester, MN 55905
Site contact: Ryan Helland · 507-422-3998 · Helland.Ryan@mayo.edu
Washington University School of Medicine - St Louis
St Louis, MO 63110
Site contact: Seth Goldberg, MD · 314-362-9096 · sgoldber@wustl.edu
Icahn School of Medicine at Mount Sinai
New York, NY 10029
Site contact: Icahn School of Medicine Mount Sinai · 212-241-2339
University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-0001
Site contact: Emily Chang, MD · 919-445-2621 · emily_chang@med.unc.edu
Brookview Hills Research Associates
Winston-Salem, NC 27103
Site contact: Janice Rogers · 336-245-6330 · jrogers@brookviewhills.com
Northeast Clinical Research Center
Bethlehem, PA 18017
Site contact: Stephanie Hanzl, RN · 610-433-4100 · steph.hanzl@necresearch.org
University of Pennsylvania
Philadelphia, PA 19104
Site contact: Krishna Kallem · krishna.kallem@pennmedicine.upenn.edu
Nephrology Associates - Chattanooga - East Third Street
Chattanooga, TN 37404
Site contact: Southeast Renal Research Institute · 423-826-8003 · research@nephassociates.com
Knoxville Kidney Center
Knoxville, TN 37923
Site contact: Tammy Conger · 865-692-3462 · tconger@knoxvillekidneycenter.com
Renal Disease Research Institute
Dallas, TX 75204
Site contact: Caren Swift · 214-366-6094 · swiftc@DNEPH.com
Swedish Medical Center - Seattle
Seattle, WA 98104
Site contact: Adel Islam · 206-215-6532 · adel.islam@swedish.org
Study contacts (from the official record)
- Calico Clinical Trial Communication · 650-754-6200 · clinicaltrialcommunication@calicolabs.com