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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

Tempus AI · with United Therapeutics · NCT06911632

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Not applicable
Target enrollment
900
US sites recruiting
40
Study start
July 23, 2025
Record last updated
October 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

MOMENTOUS is a multi-center, randomized study to prospectively evaluate the performance of an ECG-based AI device to predict whether participants with interstitial lung disease (ILD) are at high risk of undiagnosed pulmonary hypertension.

Being studied: ECG-based AI Device - Results Returned to Investigator; Echocardiogram and Right Heart Catheterization; ECG-based AI Device - Results Not Returned to Investigator

Conditions: Pulmonary Hypertension; Interstitial Lung Disease (ILD)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18 years or older at the time of consent
  • A known diagnosis of interstitial lung disease
  • Diffusing capacity for carbon monoxide (DLCO) \<30% predicted, collected within 6 months prior to consent
  • Willing and able to provide informed consent and undergo all study-specific procedures, including echo and RHC, if required

Exclusion Criteria

  • A known diagnosis of pulmonary hypertension (including patients prescribed a therapy specifically for pulmonary arterial hypertension (PAH))
  • A RHC was completed within the previous 1 year or ordered and not yet completed at the time of consent
  • LV ejection fraction ≤ 40% on most recent echo or cardiac MRI, if available
  • Unclassifiable Tempus PH ECG risk result after up to 2 ECG acquisitions
  • A contraindication to RHC exists (for example, pregnancy or mechanical right heart valve)
  • Physician decision that if a patient is directed to RHC by the study protocol, the potential risks of RHC outweigh the potential benefits
  • There is a severe concomitant illness limiting life expectancy to less than 6 months (at the discretion of the investigator)
  • There is a medical or social factor that makes the patient a poor candidate for the study and/or unlikely to be able to comply with the study protocol or complete study procedures (at the discretion of the investigator)

Recruiting US locations

  • University of Alabama at Birmingham

    Birmingham, AL 35205

    Site contact: Andrea Ford · 205-0934-8904 · afcook@uabmc.edu

  • Banner University Medical Center

    Phoenix, AZ 84006

    Site contact: Clinical Research Coordinator · 602-521-6400 · slmarch@arizona.edu

  • Dignity Health - St. Joseph's Hospital and Medical Center-Norton Thoracic Institute

    Phoenix, AZ 85013

    Site contact: Dominique Robertson · 602-406-1295 · dominique.robertson900@commonspirit.org

  • University of Arkansas

    Little Rock, AR 72205

    Site contact: Clinical Research Coordinator · 501-214-2407 · blee4@uams.edu

  • HCA Riverside Community Hospital

    Riverside, CA 92501

    Site contact: Alazzeh · 423-737-2281 · aalazzeh@pacificpulm.com

  • National Jewish Health

    Denver, CO 80206

    Site contact: Adrea Arthofer · 720-945-8608 · arthofera@NJHealth.org

  • AdventHealth Orlando

    Orlando, FL 32803

    Site contact: Kimberly Stark · 407-303-9984 · kimberly.stark@adventhealth.com

  • Northwestern University

    Chicago, IL 60611

    Site contact: Taryn Holt · 312-503-2157 · taryn.holt@northwestern.edu

  • University of Illinois Health

    Chicago, IL 60612

    Site contact: Dustin Fraidenburg, MD · 866-600-2273 · dfraiden@uic.edu

  • Indiana University Health Methodist Hospital

    Indianapolis, IN 46202

    Site contact: Isabell Mwaura · 317-274-0822 · imwaura@iu.edu

  • Community Health Network

    Indianapolis, IN 46237

    Site contact: Satish Krishnan, MD

  • University of Kentucky

    Lexington, KY 40536

    Site contact: Srushan Bhaktula · 859-323-5000 · ssh486@uky.edu

  • Willis Knighton Health

    Bossier City, LA 71111

    Site contact: Briana Barrow · bbarrow@wkhs.com

  • Louisiana State University Health Shreveport

    Shreveport, LA 71102

    Site contact: Teresa Leeth · 318-675-5920 · teresa.leeth@lsuhs.edu

  • Brigham and Women's Hospital

    Boston, MA 02115

    Site contact: Clinical Research Coordinator · 970-846-2343 · eharris@bwh.harvard.edu

  • University of Michigan - Michigan Medicine

    Ann Arbor, MI 48109-5360

    Site contact: Catherine Crombez · 734-232-4176 · cathercr@med.umich.edu

  • Corewell Health

    Royal Oak, MI 48073

    Site contact: Bobbie Lewis · 248-551-5958 · bobbie.lewis@corewellhealth.org

  • University of Minnesota

    Minneapolis, MN 55455

    Site contact: Mandi DeGrote · 612-626-7609 · carl1032@umn.edu

  • University of Mississippi Medical Center

    Jackson, MS 39216

    Site contact: Jaime Brown · jlbrown@umc.edu

  • Hannibal Regional Healthcare System

    Hannibal, MO 63401

    Site contact: 573-629-3926 · humam.farah@hannibalclinic.com

  • Mercy Hospital Springfield

    Springfield, MO 65804

    Site contact: Tracey Haertling · 508-264-5456 · nathan.frans@mercy.net

  • CHI Health Creighton University Medical Center - Bergan Mercy

    Omaha, NE 68124

    Site contact: Chloe Andersen · 402-343-8511 · chloe.andersen900@commonspirit.org

  • Renown Regional Medical Center

    Reno, NV 89502

    Site contact: Merlino · 775-982-7878 · amanda.merlino@renown.org

  • University of New Mexico

    Albuquerque, NM 87131

    Site contact: Goodale · 505-272-6794 · LGoodale@salud.unm.edu

  • University of Buffalo

    Buffalo, NY 14203

    Site contact: Kristopher Clark, MD

  • Weill Cornell University Medical College

    New York, NY 10021

    Site contact: Kimberly Kerr · 646-962-2333 · kke4001@med.cornell.edu

  • Southeastern Research Center

    Winston-Salem, NC 27103

    Site contact: Lauren Miller · 336-659-8414 · lmiller@southeasternresearchcenter.com

  • University Hospitals Cleveland Medical Center

    Cleveland, OH 44121

    Site contact: Jennie Pexa · 216-844-3201 · jennie.pexa@uhhospitals.org

  • University of Oklahoma

    Oklahoma City, OK 73104

    Site contact: Maria Mason · 405-271-6173 · Maria-l-mason@ouhsc.edu

  • Thomas Jefferson University

    Philadelphia, PA 19107

    Site contact: Mallem · 215-955-9181 · djamila.mallem@jefferson.edu

  • Temple University of The Commonwealth System of Higher Education

    Philadelphia, PA 19140

    Site contact: Kimberly Selwood · 215-707-2291 · Kim.Selwood@tuhs.temple.edu

  • Medical University of South Carolina

    Charleston, SC 29425

    Site contact: Krishna · 843-792-1794 · georgjam@musc.edu

  • University of Tennessee

    Knoxville, TN 37920

    Site contact: Herbert · 865-305-4893 · bherbert@utmck.edu

  • Baylor University Medical Center

    Dallas, TX 75246

    Site contact: Brianna Kamran · 214-820-6856 · Brianna.Kamran@bswhealth.org

  • Baylor College of Medicine

    Houston, TX 77030

    Site contact: Ivan Rosas, MD

  • Houston Methodist Hospital

    Houston, TX 77030

    Site contact: Rosa De Costa · 713-441-7182 · zsafdar@houstonmethodist.org

  • HCA Research Institute - Methodist Hospital

    San Antonio, TX 78229

    Site contact: Clinical Research Coordinator · 210-575-9500 · samantha.guerra@hcahealthcare.com

  • University of Utah

    Salt Lake City, UT 84103

    Site contact: Stefanos Lakonios · 801-581-5811 · stefan.lakonios@hsc.utah.edu

  • Virginia Commonwealth University

    Richmond, VA 23298

    Site contact: Robin Toft · 804-628-4570 · robin.toft@vcuhealth.org

  • West Virginia University Hospital

    Morgantown, WV 26505

    Site contact: Chad Glaze · 304-293-4661 · cglaze@hsc.wvu.edu

Study contacts (from the official record)

  • Momentous Study · (833) 514-4187 · momentous-study@tempus.com
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Multi-site Study of the Clinical Impact of an AI-assisted Approach… (NCT06911632) | Bored Studies