Mental health · Pennsylvania
Mental health studies in Pennsylvania
54 studies have at least one recruiting site in Pennsylvania. Mental health research includes studies of depression, anxiety, PTSD, bipolar disorder, schizophrenia and ADHD, testing medicines, devices and talk therapies.
54 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 2
RE104 Safety and Efficacy Study in Generalized Anxiety Disorder
Reunion Neuroscience Inc
- Location
- Philadelphia, PA + 26 other US sites
- Eligibility basics
- Ages 18–74
- RecruitingPhase 3
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
Transcend Therapeutics
- Location
- Plymouth Meeting, PA + 36 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
52-week Open Label Safety-Tolerability Study
LB Pharmaceuticals Inc.
- Location
- Philadelphia, PA + 22 other US sites
- Eligibility basics
- Ages 18–65
- Recruiting
A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Ksana Health
- Location
- Pittsburgh, PA + 1 other US site
- Eligibility basics
- Ages 13–24
- RecruitingPhase 3
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Neurocrine Biosciences
- Location
- Philadelphia, PA + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Syndeio Biosciences, Inc
- Location
- Allentown, PA + 20 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingPhase 2
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Syndeio Biosciences, Inc
- Location
- Philadelphia, PA + 22 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingPhase 2
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
LB Pharmaceuticals Inc.
- Location
- Philadelphia, PA + 25 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 3
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Neurocrine Biosciences
- Location
- Philadelphia, PA + 38 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
Mindfulness Training and Respiration Biosignal Feedback - Study 2
Equa Health
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–30
- Recruiting
STEPS - Stress Training and Engagement Via Phone-Based Systems
Equa Health
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–30
- Recruiting
Clinical Outcomes Study of the Nexel Total Elbow
Zimmer Biomet
- Location
- Philadelphia, PA + 3 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
AbbVie
- Location
- Allentown, PA + 46 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
Monument Therapeutics Limited
- Location
- Philadelphia, PA + 14 other US sites
- Eligibility basics
- Ages 17–30
- RecruitingPhase 2
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
atai Therapeutics, Inc.
- Location
- Moosic, PA + 33 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder
VistaGen Therapeutics, Inc.
- Location
- Plymouth Meeting, PA + 6 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
Study of ALTO-300 in MDD
Alto Neuroscience
- Location
- Allentown, PA + 36 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteers
Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program
Penn State University
- Location
- Hershey, PA + 2 other US sites
- Eligibility basics
- Ages 11+
- RecruitingHealthy volunteersPhase 4
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
VA Office of Research and Development
- Location
- Philadelphia, PA + 8 other US sites
- Eligibility basics
- Ages 40+
- RecruitingHealthy volunteersPhase 4
Anticholinergic Deprescription in Schizophrenia
Deepak K. Sarpal, M.D.
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 40–70
- RecruitingHealthy volunteers
Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation
Fabio Ferrarelli
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteers
Caregiver Stress and Sleep Study
University of Pittsburgh
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 55+
- RecruitingHealthy volunteers
Testing a Measurement Feedback App to Improve Data Quality, Supervision & Outcomes in Behavioral Health
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Neuromodulation of Brain and Emotional Responses to Psychological Stress
University of Pittsburgh
- Location
- Pittsburgh, PA
- Eligibility basics
- Ages 30–50
Who these studies look for
Studies usually require a confirmed diagnosis and stable circumstances, and they monitor safety closely. If you are in crisis, contact a crisis line or emergency services rather than a study.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Will joining affect my current treatment?
Some studies require changes to medicines, which the study team manages; others add to your usual care. Talk to your own clinician before making any change.