A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
EyeBiotech Ltd. · NCT07440225
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 50+ · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Phase 2, Phase 3
- Target enrollment
- 960
- US sites recruiting
- 67
- Study start
- March 27, 2026
- Record last updated
- October 2, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD).
Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD.
The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Being studied: Tiespectus; Aflibercept
Conditions: Macular Degeneration; Age-Related Macular Degeneration; Choroidal Neovascularization; Wet Macular Degeneration
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
The main inclusion criteria include but are not limited to the following:
- Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
- The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment
The main exclusion criteria include but are not limited to the following
- Has uncontrolled blood pressure at screening
- History of any prior macular laser photocoagulation in the study eye
- History of uveitis in either eye
- History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
- Has uncontrolled glaucoma in the study eye
- Active retinal disease other than the condition under investigation in the study eye
- Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye
Recruiting US locations
Research Network Arizona / Retina Macula Institute of Arizona
Scottsdale, AZ 85255
Site contact: Study Coordinator · 602-613-5473
Retina Center of Arkansas
Fayetteville, AR 72703
Site contact: Study Coordinator · 479-234-4499
Retina Partners of Northwest Arkansas, PLLC
Springdale, AR 72764
Site contact: Study Coordinator · 479-408-4470
Global Research Management, Inc.
Glendale, CA 91204
Site contact: 818-246-2560
Retinal Consultants Medical Group (Site 024)
Modesto, CA 95356
Site contact: Study Coordinator · 209-521-6173
Azul Vision / California Eye Specialists Medical Group, Inc.
Pasadena, CA 91107
Site contact: Study Coordinator · 661-609-2475
Retina Consultants of Southern California (Site 043)
Redlands, CA 92374
Site contact: Study Coordinator · 951-788-0222
Retinal Consultants Medical Group (Site 020)
Sacramento, CA 95825
Site contact: Study Coordinator · 916-974-9279
Retinal Consultants Medical Group (Site 022)
Sacramento, CA 95841
Site contact: Study Coordinator · 916-339-3650
Florida Eye Clinic (Site 130)
Altamonte Springs, FL 32701
Site contact: Study Coordinator · 407-775-7495
Retina Group of Florida (Site 070)
Fort Lauderdale, FL 33308
Site contact: Study Coordinator · 954-776-6880
Vitreo Retinal Associates
Gainesville, FL 32607
Site contact: 352-300-8412
Florida Retina Institute
Jacksonville, FL 32216
Site contact: Study Coordinator · 206-338-0248
Florida Retina Consultants
Lakeland, FL 33805
Site contact: Study Coordinator · 863-682-7474
South Florida Retina Institute
Miami, FL 33180
Site contact: Study Coordinator · 786-590-1777
Retina Care Specialists
Palm Beach Gardens, FL 33410
Site contact: Study Coordinator · 561-408-0853
Fort Lauderdale Eye Institute (Site 042)
Plantation, FL 33324
Site contact: Study Coordinator · 954-635-2861
Retina Vitreous Associates of Florida (Site 049)
St. Petersburg, FL 33711
Site contact: Study Coordinator · 727-323-0077
Southern Vitreoretinal Associates
Tallahassee, FL 32308
Site contact: Study Coordinator · 850-942-6700
Retina Associates of Florida, LLC
Tampa, FL 33609
Site contact: Study Coordinator · 616-438-9395
Retina Vitreous Associates of Florida
Tampa, FL 33617
Site contact: Study Coordinator · 813-987-2000
Wildwood Clinical Research / Florida Retina Institute
Wildwood, FL 34785
Site contact: Study Coordinator · 407-473-5596
Illinois Retina Associates
Oak Park, IL 60304
Site contact: Study Coordinator · 872-222-0139
Springfield Clinic
Springfield, IL 62703
Site contact: Study Coordinator · 217-528-7541
Associated Vitreoretinal and Uveitis Consultants
Carmel, IN 46032
Site contact: Study Coordinator · 317-571-1501
Midwest Eye Institute
Carmel, IN 46032
Site contact: Study Coordinator · 317-805-2152
Cumberland Valley Retina Consultants (Site 007)
Hagerstown, MD 21740
Site contact: Study Coordinator · 301-665-1712
Foundation for Vision Research (Site 073)
Grand Rapids, MI 49546
Site contact: Study Coordinator · 616-438-9395
Retina Consultants of Minnesota
Saint Louis Park, MN 55416
Site contact: Study Coordinator · 952-259-4285
Retina Specialists of Mississippi
Hattiesburg, MS 39402
Site contact: Study Coordinator · 601-255-0736
Mississippi Retina Associates (Site 084)
Madison, MS 39110
Site contact: Study Coordinator · 601-981-4091
Mid Atlantic Retina
Cherry Hill, NJ 08034
Site contact: Study Coordinator · 215-928-3092
Vision Research Center Eye Associates of New Mexico
Albuquerque, NM 87109
Site contact: Study Coordinator · 505-393-7483
ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)
Hauppauge, NY 11788
Site contact: Study Coordinator · 516-466-0390
Retina Vitreous Surgeons of CNY, PC (Site 033)
Liverpool, NY 13088
Site contact: Study Coordinator · 315-445-8166
Piedmont Retina Specialists - Greensboro
Greensboro, NC 27401
Site contact: Study Coordinator · 336-369-7160
North Carolina Retina Associates
Greenville, NC 27834
Site contact: Study Coordinator · 919-782-8038
Piedmont Retina Specialists - Winston-Salem
Winston-Salem, NC 27103
Site contact: Study Coordinator · 336-397-9216
Cincinnati Eye Institute (Site 133)
Cincinnati, OH 45242
Site contact: Study Coordinator · 513-569-3462
Retina Vitreous Center
Edmond, OK 73013
Site contact: Study Coordinator · 405-607-6699
Tulsa Retina Consultants
Tulsa, OK 74114
Site contact: Study Coordinator · 918-395-0872
Retina Northwest, PC
Portland, OR 97221
Site contact: Study Coordinator · 971-865-2781
EyeHealth Northwest
Portland, OR 97225
Site contact: Study Coordinator · 503-296-6484
Mid Atlantic Retina (Site 050)
Bethlehem, PA 18017
Site contact: Study Coordinator · 516-466-0390
Palmetto Retina Center
Aiken, SC 29803
Site contact: Study Coordinator · 803-867-7058
Charleston Neuroscience Institute - Bluffton (Site 124)
Bluffton, SC 29910
Site contact: Study Coordinator · 843-278-9938
Charleston Neuroscience Institute (Site 104)
Charleston, SC 29414
Site contact: Study Coordinator · 843-972-3857
Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina
Mt. Pleasant, SC 29464
Site contact: Study Coordinator · 843-763-4466
Charles Retina Institute
Germantown, TN 38138
Site contact: Study Coordinator · 901-683-0399
Retina Research Institute of Texas (Site 010)
Abilene, TX 79606
Site contact: Study Coordinator · 325-690-4414
Southwest Retina Specialists
Amarillo, TX 79106
Site contact: Study Coordinator · 806-350-1113
Texas Retina Associates
Arlington, TX 76012
Site contact: Study Coordinator · 682-433-5453
Austin Research Center for Retina
Austin, TX 78705
Site contact: Study Coordinator · 512-454-5851
Austin Retina Associates (Site 012)
Austin, TX 78705
Site contact: Study Coordinator · 512-451-0103
Retina & Vitreous of Texas
Bellaire, TX 77401
Site contact: Study Coordinator · 281-249-9076
Texas Retina Associates
Dallas, TX 75231
Site contact: Study Coordinator · 800-695-6941
Texas Retina (Site 037)
Plano, TX 75075
Site contact: Study Coordinator · 469-560-0177
Retina Center of Texas
Southlake, TX 76092
Site contact: Study Coordinator · 817-865-6800
Retina Consultants of Texas (Site 014)
The Woodlands, TX 77384
Site contact: Study Coordinator · 713-524-3434
Tyler Retina Research Institute
Tyler, TX 75703
Site contact: Study Coordinator · 903-597-4644
+ 7 more on the official record.
Study contacts (from the official record)
- Toll Free Number · 1-888-577-8839 · Trialsites@msd.com