A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
Novo Nordisk A/S · NCT07668388
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18–75 · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Phase 2
- Target enrollment
- 300
- US sites recruiting
- 21
- Study start
- June 22, 2026
- Record last updated
- October 7, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatment participants get is decided by chance. UBT251 is the treatment being tested and is not yet available for doctors to prescribe, while semaglutide is a medicine used to treat type 2 diabetes that doctors can already prescribe.
Being studied: UBT251; UBT251 Placebo; Semaglutide; Semaglutide Placebo
Conditions: Diabetes Mellitus, Type 2
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Male or female (sex assigned at birth, inclusive of all gender identities).
- Age 18-75 years (both inclusive) at the time of signing the informed consent.
- Diagnosed with type 2 diabetes greater than or equal to (≥) 180 days before screening.
- Stable daily dose(s) ≥ 90 days before screening of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator:
metformin with or without sodium-glucose cotransporter-2 (SGLT2) inhibitor.
- HbA1c of 7.0-10.5 percent (%) (53-91 millimoles per mole (mmol/mol)) (both inclusive) as assessed by central laboratory at screening.
- Body mass index between 25.0 kg/m\^2 and 50.0 kg/m\^2 (both inclusive) at screening.
Exclusion Criteria
- Treatment with any medication (prescription or over-the counter) or alternative remedies for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed.
- Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
- Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire, question 8.
Recruiting US locations
Flourish Research
Birmingham, AL 35205
Ark Clinical Research
Fountain Valley, CA 92708
Ark Clinical Research
Long Beach, CA 90815
Los Angeles Institute for Metabolic Research
Los Angeles, CA 90015
Catalina Research Institute, LLC
Montclair, CA 91763
Encore Medical Research LLC
Hollywood, FL 33024
South Broward Research LLC
Miramar, FL 33027
Encore Medical Research of Weston
Weston, FL 33331
Cotton O'Neil Diabetes & Endocrinology
Topeka, KS 66606
MD Medical Research
Oxon Hill, MD 20745
KDCILM, LLC & Accellacare US, Inc.
Wilmington, NC 28401
Preferred Primary Care Physicians, Inc.
Uniontown, PA 15401
Monroe Biomedical Research, LLC
North Charleston, SC 29406
LifeDoc Health
Memphis, TN 38115
IMA Clinical Research
Austin, TX 78745
Private Practice - Dr. Laila A. Hassan
Houston, TX 77089
Radiance Clinical Research
Lampasas, TX 76550
Quality Research Inc
San Antonio, TX 78209
Tekton Research Inc
San Antonio, TX 78258
Consano Clin Res-Shavano Park
Shavano Park, TX 78231
Chrysalis Clinical Research
St. George, UT 84790
Study contacts (from the official record)
- Novo Nordisk · (+1) 866-867-7178 · clinicaltrials@novonordisk.com
Similar studies in Alabama
All diabetes studies in Alabama →- RecruitingHealthy volunteersPhase 3
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Location
- Birmingham, AL + 55 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingPhase 2
Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy
Biomea Fusion Inc.
- Location
- Birmingham, AL + 19 other US sites
- Eligibility basics
- Ages 18–75
- Recruiting
Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial
Sonavex, Inc.
- Location
- Dothan, AL + 19 other US sites
- Eligibility basics
- Ages 18–84
- RecruitingPhase 3
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
Vertex Pharmaceuticals Incorporated
- Location
- Anniston, AL + 57 other US sites
- Eligibility basics
- Ages 18–80