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RecruitingPhase 2

A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia

Novartis Pharmaceuticals · NCT07610278

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
120
US sites recruiting
29
Study start
May 29, 2026
Record last updated
July 30, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a multicenter, randomized, double-blind, factorial design Phase 2 study to evaluate the pharmacodynamics, safety and tolerability of a combination of QCZ484 and inclisiran compared to QCZ484, inclisiran, and placebo in participants with hypertension and concomitant hypercholesterolemia.

Being studied: QCZ484; Inclisiran; QCZ484 placebo; Inclisiran placebo

Conditions: Hypercholesterolaemia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Males or females aged 18 to 75 years.
  • Diagnosis of primary hypertension.
  • Treatment with either no, or up to 2 antihypertensive medications at a stable dose for at least 4 weeks preceding screening.
  • Systolic blood pressure ≥140 and \<165 mmHg based on the mean of 3 sitting measurements based on office blood pressure monitoring.
  • Diagnosis of hypercholesterolemia including heterozygous familial hypercholesterolemia unable to reach LDL-C goals with a stable dose of statin treatment for at least 4 weeks prior to screening as per Investigator judgement, guidelines and local practice (if tolerated and not contraindicated) with or without bempedoic acid and with or without ezetimibe prescribed according to local guidance, at a stable dose for at least 4 weeks preceding Screening Visit 1.

The following parameters must be confirmed at Screening Visit 2:

  • Fasting serum LDL-C ≥70 mg/dL and \<190 mg/dL using Friedewald equation.
  • Fasting triglyceride \<400 mg/dL.

Exclusion Criteria

  • Symptomatic orthostatic hypotension.
  • Treatment with certain medications and/or unable to comply with prohibited medications requirements.

Other protocol inclusion/exclusion criteria may apply

Recruiting US locations

  • G and L Research LLC

    Foley, AL 36535

    Site contact: Christine S Fuller · glresearch5@gmail.com

  • The Center for Clinical Trials

    Saraland, AL 36571

    Site contact: JoAnn Ladner · joann@thecenterforclinicaltrials.com

  • Clinical Trials Research

    Lincoln, CA 95648

    Site contact: Stacy Woodward · +1 916 434 8230 · stacy@ctrsites.com

  • Downtown L A Research Center Inc

    Los Angeles, CA 90017

    Site contact: Claudia Cisneros · +1 213 261 3680 · ccisneros@dtlaresearch.com

  • Valley Clinical Trials

    Northridge, CA 91325

    Site contact: Haydee Gutierrez · hgutierrez@flourishresearch.com

  • Flourish Medical Clinical Trials

    Boca Raton, FL 33434

    Site contact: Cassandra Duff · cduff@flourishresearch.com

  • Clinical Research of Brandon LLC

    Brandon, FL 33511

    Site contact: Erika Santos · esantos@crofb.com

  • ALL Medical Research LLC

    Cooper City, FL 33024

    Site contact: Alejandro Marin · +1 754 263 2001 · amarin@allmedicalresearch.com

  • AMR Miami

    Coral Gables, FL 33134

    Site contact: Odalys Fundora · odalys.fundora@amr-clinical.com

  • Universal Axon Clinical Research

    Doral, FL 33166

    Site contact: Glenda Padron · glenda.padron@roviaclinical.com

  • East Coast Institute for Research

    Jacksonville, FL 32216

    Site contact: Carol Tunsil · +1 386 868 5625 · carol.tunsil@roviaclinical.com

  • Entrust Clinical Research

    Miami, FL 33176

    Site contact: Daimelys Garcia · Dgarcia@entrustclinicalresearch.com

  • Inpatient Research Clinical LLC

    Miami Lakes, FL 33014

    Site contact: Ilianys Marino · +1 786 502 4303 · imarino@inpatientresearch.com

  • Inpatient Research Clinical LLC

    Miami Lakes, FL 33014

    Site contact: Enrique Pacheco · epacheco@inpatientresearch.com

  • American Research Centers of FL

    Pembroke Pines, FL 33027

    Site contact: Liliana Portal · lportal@americanresearchcenters.com

  • East Coast Inst for Research LLC

    Saint Augustine, FL 32086

    Site contact: Rebecca Fink · +1 904 824 1776#116 · becca.fink@roviaclinical.com

  • East Coast Research

    Canton, GA 30114

    Site contact: Marvelyn Brentum · marvelyn.brentum@roviaclinical.com

  • Great Lakes Clinical Trials

    Chicago, IL 60640

    Site contact: Megi Stafa · +1 773 275 3500 · mstafa@flourishresearch.com

  • AMR Chicago

    Niles, IL 60714

    Site contact: Unnathi Nagelli · +1 630 491 1901 · unnathi.nagelli@amr-clinical.com

  • Alliance for Multispecialty Research

    Wichita, KS 67207

    Site contact: Shaunacie Mc Callum · shaunacie.mccallum@amr-clinical.com

  • Monroe Research Llc

    West Monroe, LA 71291

    Site contact: Nina Parrott · ninaparrottlpncrc@monroeresearch.net

  • Anderson Medical Research

    Ft. Washington, MD 20744

    Site contact: Ann-Marie Cobb · andersonmedicalresearch@gmail.com

  • Capitol Cardiology Associates

    Lanham, MD 20706

    Site contact: Iluyomade Adeusi · +1 301 312 0575 · iluyomade@capitolcardiology.com

  • Monroe Biomedical Research

    Monroe, NC 28112

    Site contact: Avrie Torres · +1 704 283 7359 · atorres@onsiteclinical.com

  • Walker Family Care

    Little River, SC 29566

    Site contact: Madelyn Poore · mpoore@littlerivercr.com

  • Synergy Group Medical LLC

    Houston, TX 77061

    Site contact: Graciela Lopez · +1 281 206 0068 · glopez@synergygroupus.com

  • Synergy Group Medical LLC

    Houston, TX 77061

    Site contact: Reina Romero · +1 832 532 4210 · rromero@synergygroupus.com

  • Manassas Clinical Research Center

    Manassas, VA 20110

    Site contact: Arleth Lopez · +1 703 330 1112 · arleth@manassasclinic.com

  • Dominion Medical Associates

    Richmond, VA 23219

    Site contact: Tara Snead · +1 804 836 6540 · tara@dominionmedicalinc.com

Study contacts (from the official record)

  • Novartis Pharmaceuticals · 1-888-669-6682 · novartis.email@novartis.com
  • Novartis Pharmaceuticals
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A Study to Evaluate the Pharmacodynamics of a Combination of… (NCT07610278) | Bored Studies