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Childhood Cancer Survivor Study

St. Jude Children's Research Hospital · with National Cancer Institute (NCI), Fred Hutchinson Cancer Center · NCT01120353

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Any age listed · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
50000
US sites recruiting
27
Study start
January 5, 1995
Record last updated
June 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

Conditions: Cancer

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Initial Cohort

  • Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort

  • Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
  • English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.

Exclusion Criteria

  • Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
  • Non-English speaking or residence outside the US or Canada.

Sibling Controls

  • For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.

Recruiting US locations

  • University of Alabama at Birmingham/Children's of Alabama

    Birmingham, AL 35294

    Site contact: Kimberly Whelan, MD · 202-939-9285 · kwhelan@peds.uab.edu

  • City of Hope National Medical Center

    Duarte, CA 91010

    Site contact: Saro Armenian, DO · 626-471-7205 · sarmenian@coh.org

  • Children's Hospital Los Angeles

    Los Angeles, CA 90027

    Site contact: David Freyer, DO · 323-361-8953 · DFreyer@chla.usc.edu

  • University of California-Los Angeles

    Los Angeles, CA 90095

    Site contact: Jacqueline Casillas, MD · 310-794-2474 · jcasillas@mednet.ucla.edu

  • Children's Hospital of Orange County

    Orange, CA 92868

    Site contact: Leonard Sender, MD · 714-509-8636 · lsender@uci.edu

  • University of California-San Francisco

    San Francisco, CA 94143

    Site contact: Robert Goldsby, MD · 415-476-3831 · goldsbyr@peds.ucsf.edu

  • Stanford University School of Medicine

    Stanford, CA 94305

    Site contact: Sheri Spunt, MD · 650-723-5535 · sspunt@stanford.edu

  • Children's Hospital Colorado

    Aurora, CO 80045

    Site contact: Brian Greffe, MD · 720-777-6787 · greffe.brian@tchden.org

  • Children's National Medical Center

    Washington D.C., DC 20010

    Site contact: Jennifer Dean, MD · 703-531-3627 · jdean@psvcare.org

  • Emory University/Children's Health Care of Atlanta

    Atlanta, GA 30322

    Site contact: Lillian Meacham, MD · 404-727-0480 · lillian.meacham@oz.ped.emory.edu

  • Ana & Robert H. Lurie Children's Hospital of Chicago

    Chicago, IL 60611-2605

    Site contact: Jennifer Reichek, MD, MSW · 312-227-4777 · jreichek@luriechildrens.org

  • University of Chicago

    Chicago, IL 60637

    Site contact: Tara Henderson, MD, MPH · 773-702-2501

  • Indiana University/Riley Hospital for Children

    Indianapolis, IN 46202

    Site contact: Terry Vik, MD · 317-944-8784 · tvik@iupui.edu

  • Dana-Farber Cancer Institute

    Boston, MA 02215

    Site contact: Lisa Diller, MD · 617-632-5642 · lisa_diller@dfci.harvard.efu

  • University of Michigan/Mott Children's Hospital

    Ann Arbor, MI 48109

    Site contact: Raymond Hutchinson, MD · 734-764-7126 · rhutchin@umich.edu

  • Children's Hospitals & Clinics of Minnesota

    Minneapolis, MN 55404

    Site contact: Katharine R. Lange, MD · 612-813-6560 · Katharine.Lange@childrensmn.org

  • St. Louis Children's Hospital/The Washington University

    St Louis, MO 63130

    Site contact: Robert Hayashi, PhD · 314-454-4118 · hayashi_r@kids.wustl.edu

  • Roswell Park Cancer Institute

    Buffalo, NY 14263

    Site contact: Denise Rokitka, MD · 716-845-2333 · denise.rokitka@roswellpark.org

  • Memorial-Sloan Kettering Cancer Center

    New York, NY 10065

    Site contact: Danielle Friedman, MD · 212-639-8138 · friedmad@mskcc.org

  • Nationwide Children's Hospital

    Columbus, OH 43205

    Site contact: Randy Olshefski · 614-722-3553 · randal.olshefski@nationwidechildrens.org

  • Children's Hospital of Philadelphia

    Philadelphia, PA 19104

    Site contact: Jill Ginsberg, MD · 215-590-7399 · ginsbergji@email.chop.edu

  • Children's Hospital of Pittsburgh

    Pittsburgh, PA 15213

    Site contact: Jean Tersak, MD · 412-692-5963 · jean.tersak@chp.edu

  • St. Jude Children's Research Hospital

    Memphis, TN 38105

    Site contact: Gregory T. Armstrong, MD, MSCE · 888-226-4343 · ccss@stjude.org

  • Cook Children's Medical Center

    Fort Worth, TX 76104

    Site contact: Donald Beam, MD · 682-885-4007 · donald.beam@cookchildrens.org

  • M.D. Anderson Cancer Center

    Houston, TX 77030

    Site contact: Louise Strong, MD · 713-792-2589 · lstrong@mdanderson.org

  • Texas Children's Hospital

    Houston, TX 77030

    Site contact: ZoAnn E. Dreyer, MD · 832-822-4209 · zdreyer@bcm.edu

  • Seattle Children's Hospital

    Seattle, WA 98105

    Site contact: Scott Baker, MD · 206-884-1018 · ksbaker@fhcrc.org

Study contacts (from the official record)

  • Gregory T. Armstrong, MD, MSCE · 888-226-4343 · referralinfo@stjude.org
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Childhood Cancer Survivor Study (NCT01120353) | Bored Studies