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Neonatal Platelet Transfusion Threshold Trial

NICHD Neonatal Research Network · with National Heart, Lung, and Blood Institute (NHLBI) · NCT06676904

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Any age listed · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
2433
US sites recruiting
20
Study start
June 13, 2025
Record last updated
March 25, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without major or severe bleeding up to 40 0/7 weeks' postmenstrual age (PMA).

Being studied: Higher Platelet Transfusion Threshold; Lower Platelet Transfusion Threshold

Conditions: Thrombocytopenia; Neonatal; Platelet Transfusion; Infant, Newborn, Diseases; Infant, Extremely Low Birth Weight; Infant, Small for Gestational Age; Thrombosis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Gestational age of 23 0/7 to 26 6/7 weeks
  • Postnatal age of \< 48 hours

Exclusion Criteria

  • Comfort care or withdrawal of care planned
  • Neonatal alloimmune thrombocytopenia or suspected/confirmed congenital platelet or bleeding disorder
  • Receipt of platelet transfusion
  • No receipt of Vitamin K
  • Parents/guardian decline consent

Recruiting US locations

  • University of Alabama at Birmingham

    Birmingham, AL 35233

    Site contact: Waldemar A Carlo, MD

  • Stanford University

    Palo Alto, CA 94304

    Site contact: Valerie Chock, MD

  • Sharp Mary Birch Hospital for Women & Newborns

    San Diego, CA 92123

    Site contact: Anup Katheria, MD

  • University of Colorado

    Aurora, CO 80045

    Site contact: Sunah Hwang, MD

  • Emory University

    Atlanta, GA 30303

    Site contact: Ravi Patel, MD

  • Northwestern Lurie Children's Hospital of Chicago

    Chicago, IL 60611

    Site contact: Aaron Hamvas, MD

  • University of Iowa

    Iowa City, IA 52242

    Site contact: Tarah Colaizy, MD, MPH · 319-356-3508

  • Beth Israel Deaconess Medical Center

    Boston, MA 02215

    Site contact: Helen Healy, MD

  • University of New Mexico

    Albuquerque, NM 87131

    Site contact: Janell Fuller, MD

  • University of Rochester

    Rochester, NY 14642

    Site contact: Carl T D'Angio, MD

  • Duke University

    Durham, NC 27710

    Site contact: Michael Cotten, MD

  • Cincinnati Children's Medical Center

    Cincinnati, OH 45267

    Site contact: Stephanie Merhar, MD MS

  • Case Western Reserve University, Rainbow Babies and Children's Hospital

    Cleveland, OH 44106

    Site contact: Anna Maria Hibbs, MD

  • Nationwide Children's Hospital

    Columbus, OH 43205

    Site contact: Pablo Sanchez, MD

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Sara DeMauro, MD

  • Vanderbilt University

    Nashville, TN 37232

    Site contact: Hendrick Weitkamp, MD

  • University of Texas Southwestern Medical Center at Dallas

    Dallas, TX 75235

    Site contact: Myra Myckoff, MD

  • University of Texas Health Science Center at Houston

    Houston, TX 77030

    Site contact: Jon Tyson

  • Pediatrix Medical Group

    San Antonio, TX 78229

    Site contact: Kaashif Ahmad, MD

  • University of Utah

    Salt Lake City, UT 84108

    Site contact: Robin Ohls, MD

Study contacts (from the official record)

  • Ravi M Patel, MD · 404-727-5905 · rmpatel@emory.edu
  • Abhik Das, PhD · 301-230-4640 · adas@rti.org
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Neonatal Platelet Transfusion Threshold Trial (NCT06676904) | Bored Studies