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RecruitingAccepts healthy volunteersPhase 4

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Duke University · with National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI) · NCT04262206

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 75+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
20000
US sites recruiting
89
Study start
September 1, 2020
Record last updated
September 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.

Being studied: Atorvastatin 40 Mg Oral Tablet; Placebo oral tablet

Conditions: Cognitive Impairment, Mild; Dementia; Cardiovascular Diseases

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Community-dwelling adults
  • Age ≥75 years
  • English or Spanish as primary language
  • Able to provide a trusted contact

Exclusion Criteria

  • Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
  • Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
  • Dementia (clinically evident or previously diagnosed)
  • Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of urinary or bowel continence)
  • Severe hearing impairment (preventing phone follow up)
  • Unable to talk (preventing phone follow up)
  • Statin use in the past year or for longer than 5 years previously (participant reported)
  • Ineligible to take atorvastatin 40 mg (clinician determined)
  • Documented intolerance to statins
  • Active Liver Disease

Recruiting US locations

  • University of Alabama at Birmingham

    Birmingham, AL 35205

    Site contact: Destiny Taylor · 205-224-2567 · destiny.taylor@uabmc.edu

  • Birmingham VA

    Birmingham, AL 35233

    Site contact: Donald Davis · 205-933-8101 · Donald.Davis@va.gov

  • Southern Arizona VA Health Care System - Tucson

    Tucson, AZ 85723

    Site contact: Sarah Miranda · (520)792-1450 · sarah.miranda1@va.gov

  • Little Rock VA Medical Center

    Little Rock, AR 72114

    Site contact: Bonnie Dawson · 501-257-2523 · Bonnie.Dawson2@va.gov

  • University of Arkansas for Medical Sciences

    Little Rock, AR 72204

    Site contact: Patricia Savary · 501-5265701 · PESavary@uams.edu

  • Fresno VA Medical Center

    Fresno, CA 93703

    Site contact: Kieu Chau · 559-225-6100 · Kieu.chau@va.gov

  • Long Beach VA Medical Center

    Long Beach, CA 90822

    Site contact: Celine Kogane · 562-826-8000 · celine.kogane@va.gov

  • VA Greater Los Angeles

    Los Angeles, CA 90073

    Site contact: MIkayla Guerrero · 310-478-3711 · mikayla.guerrero@va.gov

  • VA Northern California Health Care System

    Mather, CA 95655

    Site contact: Maria Spinelli · 925-895-5196 · maria.spinelli@va.gov

  • VA San Diego Medical Center

    San Diego, CA 92161

    Site contact: Melissa St. John · 858-642-1129 · Melissa.St.John@va.gov

  • Yale University

    New Haven, CT 06520

    Site contact: Meilyn Madrigal · 203-737-2252 · meilyn.madrigal@yale.edu

  • VA Connecticut Healthcare System

    West Haven, CT 006111

    Site contact: Study Coordinator · 203-932-5711

  • Bay Pines VA

    Bay Pines, FL 33744

    Site contact: Anna Rosenblatt · 727-398-6661 · anna.rosenblatt2@va.gov

  • Gainesville VA Medical Center

    Gainesville, FL 32608

    Site contact: Laura Dixon · 352-548-7707 · Laura.dixon1@va.gov

  • University of Florida

    Gainesville, FL 32610

    Site contact: Monika Guirguis · 352-273-5919 · recruit@aging.ufl.edu

  • University of Florida

    Jacksonville, FL 32608

    Site contact: Renae Burr · 904-244-4690 · JAX-ASCENT@jax.ufl.edu

  • University of Miami

    Miami, FL 33136

    Site contact: Yesenia Levi · 786-877-7710 · yxl878@miami.edu

  • Atlanta VA Medical Center

    Atlanta, GA 30033

    Site contact: Mechelle Lockhart · 404-315-4100 · Mechelle.lockhart@va.gov

  • Emory University

    Atlanta, GA 30322

    Site contact: William Brown · 770-330-7790 · mindandheart@emory.edu

  • Northwestern University

    Chicago, IL 60208

    Site contact: Holly Herman · 312-503-4639 · holly.herman@northwestern.edu

  • University of Illinois at Chicago

    Chicago, IL 60608

    Site contact: Naomi Ashley · 1-312-355-0083 · naomiab@uic.edu

  • Chicago VA Medical Center/Jesse Brown VA

    Chicago, IL 60612

    Site contact: Naomi Ashley · 312-569-7339 · naomi.ashley@va.gov

  • Rush University Medical Center

    Chicago, IL 60612

    Site contact: Erin Yurko · 312-942-6596 · erin_yurko@rush.edu

  • University of Chicago

    Chicago, IL 60637

    Site contact: Matt Carlson · 210-908-7749 · mcarlson1@medicine.bsd.uchicago.edu

  • Hines VA Medical Center

    Hines, IL 60141

    Site contact: Holly Kramer, MD · 708-202-8387 · Holly.Kramer@va.gov

  • North Chicago VA Medical Center

    North Chicago, IL 60064

    Site contact: Erica Noel · 224-610-7140 · erica.noel@va.gov

  • Indianapolis VA Medical Center

    Indianapolis, IN 46202

    Site contact: Jared Ferguson · 317-988-9833 · jared.ferguson2@va.gov

  • University of Iowa Healthcare

    Iowa City, IA 52242

    Site contact: Samantha Shaffer · 319-678-7053 · samantha-shaffer@uiowa.edu

  • University of Kansas Medical Center

    Kansas City, KS 66160

    Site contact: Erica Lower · 913-588-6052 · elower@kumc.edu

  • VA Eastern Kansas Healthcare System

    Topeka, KS 66622

    Site contact: Karen Reuben-Hallock · 913-682-2000 · Karen.Reuben-Hallock@va.gov

  • Louisville VA Medical Center

    Louisville, KY 40206

    Site contact: Jordan Ricks · 502-287-5208 · Jordan.Ricks@va.gov

  • Ochsner Clinic Foundation

    New Orleans, LA 70121

    Site contact: Shannon Williams · 504-842-6487 · slwilliams@ochsner.org

  • Maine VA Health Care System

    Togus, ME 04330

    Site contact: Houlton Boomer · 207-623-8411 · houlton.boomer@va.gov

  • Johns Hopkins University

    Baltimore, MD 21287

    Site contact: Megan Gauvey-Kern · 443-242-4126 · PREVENTABLE@jhmi.edu

  • VA Boston Healthcare System

    Boston, MA 02130

    Site contact: Enzo Yaksic · 617-637-5139 · Enzo.Yaksic@va.gov

  • VA Ann Arbor Healthcare System

    Ann Arbor, MI 48105

    Site contact: Mariam Toma · 734-883-0016 · mariam.toma@va.gov

  • University of Michigan

    Ann Arbor, MI 48109

    Site contact: Martina Nabozny · 734-385-6150 · mgrenier@med.umich.edu

  • Essentia Health

    Duluth, MN 55805

    Site contact: Leah Tatalovich · 218-576-0506 · PREVENTABLE@EssentiaHealth.org

  • Mayo Clinic

    Rochester, MN 55905

    Site contact: Angela Meilander · 507-293-9539 · RSTPREVENTSTUDY@mayo.edu

  • University of Mississippi Medical Center

    Jackson, MS 39216

    Site contact: Lane Boyer · 601-815-8702 · kboyer@umc.edu

  • VA Medical Center Jackson

    Jackson, MS 39216

    Site contact: Anita K Spencer · 601-362-4471 · anita.spencer@va.gov

  • University of Missouri Health System

    Columbia, MO 65212

    Site contact: Vickie Grieshaber · 833-499-1938 · mupreventable@health.missouri.edu

  • Kansas City VA Medical Center

    Kansas City, MO 64128

    Site contact: Shamsa Kiran · 816-861-4700 · Shamsa.Kiran@va.gov;

  • St. Louis VA Medical Center

    St Louis, MO 63106

    Site contact: Maureen Dempsey · 314-750-1591 · maureen.dempsey@va.gov

  • Washington University in St. Louis

    St Louis, MO 63130

    Site contact: Amy Young · 314-273-0338 · amyyoung@wustl.edu

  • University of Nebraska Medical Center

    Omaha, NE 67105

    Site contact: Amy Peterson · 1-402-552-7737 · preventable@unmc.edu

  • Omaha VA Medical Center

    Omaha, NE 68105

    Site contact: Ari Bader · 402-552-7737 · ari.bader@va.gov

  • Northwell Health

    Manhasset, NY 11030

    Site contact: Julie DiGregorio · 516-493-7950 · jdigregori@northwell.edu

  • VA New York Harbor Healthcare System

    New York, NY 10010

    Site contact: Natalie Nejaime · 212-951-3395 · natalie.nejaime@va.gov

  • Weill Cornell Medical College

    New York, NY 10021

    Site contact: Fernando Park · 607-204-9070 · preventable@med.cornell.edu

  • Albert Einstein College of Medicine

    The Bronx, NY 10461

    Site contact: Yessica E Vanterpool · 718-430-3422 · yessica.estrellavanterpool@einsteinmed.edu

  • Bronx VA Medical Center

    The Bronx, NY 10468

    Site contact: Raynier Baez · 718-584-9000 · raynier.baezguerrero@va.gov

  • Asheville VA-Charles George VA Medical Center

    Asheville, NC 28805

    Site contact: Kathleen Betts · 828-298-7911 · kathleen.betts@va.gov

  • University of North Carolina

    Chapel Hill, NC 27599

    Site contact: Jeannie Ake · 919-966-9003 · UNC_PREV@office.unc.edu

  • Atrium Health

    Charlotte, NC 28207

    Site contact: Kelsey Strout · 704-304-8394 · preventablestudy@atriumhealth.org

  • PREVENTABLE Tele-Site

    Durham, NC 27701

    Site contact: Khaula Baloch

  • Duke University

    Durham, NC 27710

    Site contact: Trina Phan · 919-684-9176 · DukePREVENTABLE@duke.edu

  • Duke University - Kannapolis

    Kannapolis, NC 28081

    Site contact: Jennifer Stiller · 704-640-7616 · preventable-kannapolis@dm.duke.edu

  • Wake Forest Baptist Hospital-Cardiology

    Winston-Salem, NC 27157

    Site contact: Sophia Dawson · 336-713-2338 · sadawson@wakehealth.edu

  • Wake Forest Hospital - Geriatrics

    Winston-Salem, NC 27157

    Site contact: Jesus Betancourt · 336-713-8659 · jbetanco@wakehealth.edu

+ 29 more on the official record.

Study contacts (from the official record)

  • Pamela Monds · 9196688695 · pamela.monds@duke.edu
  • Beth Harris · 9196688700 · Elizabeth.C.Harris@duke.edu
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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in… (NCT04262206) | Bored Studies