Older adults · Massachusetts
Studies for adults 50 and older in Massachusetts
These studies set a minimum age of 50 or older in their official record. Many look at conditions more common with age, and some vaccine and memory studies specifically need older participants.
68 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Sanofi
- Location
- Boston, MA + 49 other US sites
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation
General Biophysics LLC
- Location
- Boston, MA
- Eligibility basics
- Ages 55–75
- RecruitingHealthy volunteersPhase 1
Safety and Tolerability Trial of Psilocybin in Healthy Older Adults
University of Colorado, Denver
- Location
- Boston, MA + 5 other US sites
- Eligibility basics
- Ages 65–85
- RecruitingHealthy volunteersOvernight stay mentioned
The Osteoarthritis Prevention Study
Wake Forest University
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 50+ · Women only
- RecruitingHealthy volunteersEarly Phase 1
The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma
MCPHS University
- Location
- Worcester, MA
- Eligibility basics
- Ages 50–100
- RecruitingHealthy volunteersEarly Phase 1
PET Imaging Evaluation of [11C]SY08
Massachusetts General Hospital
- Location
- Charlestown, MA
- Eligibility basics
- Ages 50–80
- RecruitingHealthy volunteersPhase 1/Phase 2
Assess Fibrin in Brains With AD/ADRD
Massachusetts General Hospital
- Location
- Boston, MA
- Eligibility basics
- Ages 55–90
- RecruitingHealthy volunteersPhase 3
A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older
Pfizer
- Location
- West Roxbury, MA + 138 other US sites
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteers
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly, Inc.
- Location
- Boston, MA + 121 other US sites
- Eligibility basics
- Ages 55+
- RecruitingHealthy volunteersPhase 3
A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age
GlaxoSmithKline
- Location
- Boston, MA + 130 other US sites
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteers
US Benchmarking Clinical Study
eMyosound SAS
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 3
[18F]PI-2620 Phase 3 Histopathological Study
Lantheus Biosciences Ltd.
- Location
- Braintree, MA + 16 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 2
A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
Sanofi
- Location
- Newton, MA + 9 other US sites
- Eligibility basics
- Ages 55–85
- RecruitingPhase 2
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Merck Sharp & Dohme LLC
- Location
- Newton, MA + 34 other US sites
- Eligibility basics
- Ages 50–85
- RecruitingPhase 3
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
Hoffmann-La Roche
- Location
- Boston, MA + 67 other US sites
- Eligibility basics
- Ages 50–90
- RecruitingPhase 4
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
Alpha Cognition, Inc
- Location
- Methuen, MA + 21 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 3
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
Bristol-Myers Squibb
- Location
- Newton, MA + 10 other US sites
- Eligibility basics
- Ages 55–90
- RecruitingPhase 3
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Bristol-Myers Squibb
- Location
- Newton, MA + 21 other US sites
- Eligibility basics
- Ages 55–90
- RecruitingPhase 3
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration
Amgen
- Location
- Boston, MA + 54 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 3
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Regeneron Pharmaceuticals
- Location
- Boston, MA + 144 other US sites
- Eligibility basics
- Ages 50–85
- RecruitingPhase 2
A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Novartis Pharmaceuticals
- Location
- Boston, MA + 14 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 2
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
Eli Lilly and Company
- Location
- Foxborough, MA + 29 other US sites
- Eligibility basics
- Ages 55–85
- RecruitingPhase 2
Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
Lighthouse Pharmaceuticals, Inc.
- Location
- Boston, MA + 36 other US sites
- Eligibility basics
- Ages 55–80
- RecruitingPhase 2
Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease
Celgene
- Location
- Foxborough, MA + 31 other US sites
- Eligibility basics
- Ages 55–90