Older adults · Massachusetts
Studies for adults 50 and older in Massachusetts
These studies set a minimum age of 50 or older in their official record. Many look at conditions more common with age, and some vaccine and memory studies specifically need older participants.
68 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
Bristol-Myers Squibb
- Location
- Newton, MA + 23 other US sites
- Eligibility basics
- Ages 60–85
- RecruitingPhase 3
A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease
Hoffmann-La Roche
- Location
- Boston, MA + 52 other US sites
- Eligibility basics
- Ages 50–85
- RecruitingPhase 2/Phase 3
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Janssen Research & Development, LLC
- Location
- Boston, MA + 44 other US sites
- Eligibility basics
- Ages 60+
- RecruitingPhase 2
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
Intra-Cellular Therapies, Inc.
- Location
- Boston, MA + 22 other US sites
- Eligibility basics
- Ages 55+
- RecruitingPhase 3
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Location
- Belmont, MA + 43 other US sites
- Eligibility basics
- Ages 55–90
- RecruitingPhase 1/Phase 2
A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
AbbVie
- Location
- Watertown, MA + 10 other US sites
- Eligibility basics
- Ages 50–90
- Recruiting
The BRAIN App (Phase 2 SBIR)
Hopeful Aging
- Location
- Winchester, MA
- Eligibility basics
- Ages 65+
- RecruitingPhase 2
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
ONL Therapeutics
- Location
- Springfield, MA + 55 other US sites
- Eligibility basics
- Ages 55+
- RecruitingPhase 3
Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Dompé Farmaceutici S.p.A
- Location
- Boston, MA + 13 other US sites
- Eligibility basics
- Ages 50–80
- RecruitingPhase 1
A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
Astellas Institute for Regenerative Medicine
- Location
- Boston, MA + 12 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)
Skyline Therapeutics (US) Inc.
- Location
- Boston, MA + 2 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
4D Molecular Therapeutics
- Location
- Boston, MA + 19 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 2/Phase 3
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
EyeBiotech Ltd.
- Location
- Springfield, MA + 51 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1
Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants
Regeneron Pharmaceuticals
- Location
- East Weymouth, MA + 4 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 3
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
Anthos Therapeutics, Inc.
- Location
- Boston, MA + 131 other US sites
- Eligibility basics
- Ages 65+
- RecruitingPhase 3
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
Eli Lilly and Company
- Location
- Newton, MA + 41 other US sites
- Eligibility basics
- Ages 55+
- RecruitingPhase 2/Phase 3
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
Kardigan, Inc.
- Location
- Boston, MA + 46 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 2
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Novartis Pharmaceuticals
- Location
- Boston, MA + 29 other US sites
- Eligibility basics
- Ages 50–80
- Recruiting
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR
Edwards Lifesciences
- Location
- Boston, MA + 49 other US sites
- Eligibility basics
- Ages 65+
- Recruiting
Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD
VisionCare, Inc.
- Location
- Lawrence, MA + 9 other US sites
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteers
Following the Sound of Music
Northeastern University
- Location
- Boston, MA
- Eligibility basics
- Ages 60–101
- RecruitingHealthy volunteers
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
Mayo Clinic
- Location
- Boston, MA + 1 other US site
- Eligibility basics
- Ages 65+
- RecruitingHealthy volunteers
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
Beth Israel Deaconess Medical Center
- Location
- Boston, MA
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteers
Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
Boston University Charles River Campus
- Location
- Boston, MA
- Eligibility basics
- Ages 50–100