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Bored Studies
RecruitingPhase 2/Phase 3

Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

Kardigan, Inc. · NCT07001800

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2, Phase 3
Target enrollment
1276
US sites recruiting
47
Study start
June 27, 2025
Record last updated
July 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.

Being studied: Ataciguat; Placebo

Conditions: Moderate Aortic Valve Stenosis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Key Inclusion Criteria

  • Adult male or female at least 50 years of age
  • Has moderate CAVS as defined by:
  • An AVA of ≥1.0 cm2 to ≤1.50 cm2
  • An AVC score between >300 to 1200 Agatston units (AU) for women and between >300 to 2000 AU for men
  • Has a left ventricular ejection fraction (EF) of ≥45% at the time of Screening as determined by the echocardiography Imaging Core Laboratory
  • For participants in CPET sub-study in Part A and all participants in Part B: If on beta blockade, the dose must be stable for at least 90 days prior to the Screening Visit with no anticipated changes during the study

Key Exclusion Criteria

  • For participants in the CPET sub-study in Part A and all participants in Part B: Has any medical or physical condition that, in the Investigator's opinion, could lead to an inability to complete Protocol-required CPET procedures (eg, pulmonary disease, joint, leg, hip, back conditions that limit physical activity, or other absolute contraindications for CPET)
  • Anticipated or planned prior aortic valve replacement, repair, surgery, or intervention in the next 6 months
  • Has moderate, moderate-to-severe, or severe (Grade 2 or higher) mitral stenosis, mitral regurgitation, and/or aortic regurgitation
  • Has suspected or known congenital aortic valve disease including bicuspid aortic valve
  • New York Heart Association (NYHA) Class IV heart failure symptoms and/or requires continuous inotropes
  • Has history of hypertrophic, genetic/familial cardiomyopathy or cardiomyopathy related to amyloid or sarcoid
  • Has untreated obstructive coronary artery disease or anticipating coronary stenting surgery
  • Abnormal electrocardiogram (ECG) results or long-standing persistent or permanent atrial fibrillation

Recruiting US locations

  • University of Alabama at Birmingham (UAB) - Medical Center

    Birmingham, AL 35233

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Heart Center Research LLC

    Huntsville, AL 35801

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • National Heart Institute

    Beverly Hills, CA 90211

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, CA 92663

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Profound Research LLC at Southern California Heart Specialists

    Pasadena, CA 91105

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • University of California, San Francisco (UCSF) - Medical Center

    San Francisco, CA 94143

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center

    Torrance, CA 90502

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • HCA Florida - JFK Hospital

    Atlantis, FL 33462

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • New Generation of Medical Research

    Hialeah, FL 33016

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Jacksonville Center for Clinical Research

    Jacksonville, FL 32216

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • New Generation of Medical Research - Naples

    Naples, FL 34116

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Flourish Research - St. Augustine

    Saint Augustine, FL 32086

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Sarasota Memorial Hospital

    Sarasota, FL 34239

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • University of South Florida

    Tampa, FL 33606

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Northwestern University The Feinberg School of Medicine

    Chicago, IL 60611

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Ascension Heart and Vascular/Alexian Brothers Heart & Vascular Institute

    Elk Grove Village, IL 60007

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • NorthShore University Health System

    Glenview, IL 60026

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Midwest Cardiovascular Institute

    Naperville, IL 60540

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Methodist Medical Center of Illinois

    Peoria, IL 61636

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Midwest Cardiovascular Research and Education Foundation

    Elkhart, IN 46514

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • University of Louisville Health

    Louisville, KY 40202

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • University of Maryland Medical Center

    Baltimore, MD 21201

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Johns Hopkins University School of Medicine

    Baltimore, MD 21287

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Brigham and Women's Hospital

    Boston, MA 02115

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Corewell Health

    Royal Oak, MI 48073

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Henry Ford Hospital

    West Bloomfield, MI 48322

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Mayo Clinic - Rochester

    Rochester, MN 55905

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Washington University

    St Louis, MO 63110

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Albany Medical Center

    Albany, NY 12208

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Montefiore Medical Center

    The Bronx, NY 10467

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Duke University School of Medicine

    Durham, NC 27710

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health

    Greensboro, NC 27401

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Sanford Fargo

    Fargo, ND 58122

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • The Lindner Center for Research and Education at The Christ Hospital

    Cincinnati, OH 45219

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Cleveland Clinic

    Cleveland, OH 44195

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Ascension St. John Hospital

    Tulsa, OK 74104

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • University of Pittsburgh Medical Center

    Pittsburgh, PA 15213

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • OnSite Clinical Solutions, LLC - Rock Hill

    Rock Hill, SC 29732

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • TriStar Centennial Medical Center

    Nashville, TN 37203

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Vanderbilt University Medical Center

    Nashville, TN 37232

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • St. David's Heart and Vascular dba Austin Heart - Main Office

    Austin, TX 78705

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Houston Methodist Hospital

    Houston, TX 77030

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Baylor Scott and White - The Heart Hospital Baylor Plano

    Plano, TX 75093

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • Methodist Hospital - San Antonio

    San Antonio, TX 78229

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

  • University of Utah Hospital & Clinics

    Salt Lake City, UT 84112

    Site contact: Kardigan Clinical Study Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio

Study contacts (from the official record)

  • Kardigan Clinical Trial Information Team · 1-877-310-5135 · clinicaltrials@kardigan.bio
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