Study type
Pain studies recruiting now
Pain research covers chronic back pain, fibromyalgia, nerve pain and short-term pain after procedures, testing medicines, devices and non-drug approaches.
115 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
More recruiting studies (pay not posted)
- RecruitingPhase 3
Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design
Axsome Therapeutics, Inc.
- Location
- Glendale, AZ + 48 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain
Eli Lilly and Company
- Location
- Phoenix, AZ + 31 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
Eli Lilly and Company
- Location
- Birmingham, AL + 35 other US sites
- Eligibility basics
- Ages 40+
- RecruitingPhase 2
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
Pacira Pharmaceuticals, Inc
- Location
- Huntington Beach, CA + 2 other US sites
- Eligibility basics
- Ages 45–80
- Recruiting
Ultrasonic Neuromodulation of Cingulate Cortex for Fibromyalgia
SPIRE Therapeutics Inc.
- Location
- Ann Arbor, MI + 7 other US sites
- Eligibility basics
- Ages 22+
- Recruiting
VETERANS AFFAIRS AUGUSTA
Companion IQ, Inc
- Location
- Augusta, GA
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy
Vertex Pharmaceuticals Incorporated
- Location
- Birmingham, AL + 69 other US sites
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
EicOsis Human Health Inc.
- Location
- Augusta, GA
- Eligibility basics
- Ages 18+
- Recruiting
BioPoly® Partial Resurfacing Knee Implant IDE
BioPoly LLC
- Location
- Fort Wayne, IN + 3 other US sites
- Eligibility basics
- Ages 30–65
- RecruitingPhase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain
Eli Lilly and Company
- Location
- Birmingham, AL + 35 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)
Sangamo Therapeutics
- Location
- Scottsdale, AZ + 5 other US sites
- Eligibility basics
- Ages 18+
- Recruiting
NT-II™ Collagen for Joint Discomfort and Function
Hofseth Biocare ASA
- Location
- San Francisco, CA
- Eligibility basics
- Ages 20–65
- Recruiting
PerQdisc Traditional Feasibility Trial.
Spinal Stabilization Technologies
- Location
- Phoenix, AZ + 4 other US sites
- Eligibility basics
- Ages 22–70
- RecruitingPhase 2
A Study of LY4515100 in Participants With Pain Following Third Molar Removal
Eli Lilly and Company
- Location
- Salt Lake City, UT
- Eligibility basics
- Ages 18–40
- RecruitingPhase 1
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
Centrexion Therapeutics
- Location
- Napa, CA
- Eligibility basics
- Ages 18–75
- Recruiting
Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion
Kuros Biosurgery AG
- Location
- Irvine, CA + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
PF614 Analgesic Activity in Acute Postoperative Pain (PF614-301)
Ensysce Biosciences
- Location
- Atlanta, GA + 2 other US sites
- Eligibility basics
- Ages 18–75
- Recruiting
Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software
AugMend Health Inc.
- Location
- Cambridge, MA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery
Pacira Pharmaceuticals, Inc
- Location
- Indianapolis, IN + 4 other US sites
- Eligibility basics
- Ages 0 mo–6
- Recruiting
Use of the Neurolyser XR for the Treatment of Low Back Pain Related to Sacroiliitis
FUSMobile Inc.
- Location
- Charlottesville, VA
- Eligibility basics
- Ages 18+
- Recruiting
Retrospective-Prospective PNS Study
Curonix LLC
- Location
- Cleveland, OH
- Eligibility basics
- Ages 18+
- Recruiting
Freedom-1 Study for Chronic Knee Pain
Curonix LLC
- Location
- Placentia, CA + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 2
Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)
Evon Medics LLC
- Location
- Washington D.C., DC + 1 other US site
- Eligibility basics
- Ages 18–85
- RecruitingEarly Phase 1
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis
R3 Medical Research
- Location
- Scottsdale, AZ + 4 other US sites
- Eligibility basics
- Ages 30+
Who these studies look for
Studies usually set a pain score range and limits on pain medicines. Some short-term pain studies involve a scheduled minor procedure.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
What is an acute pain study?
Some studies measure pain relief after a planned minor procedure, such as dental surgery or bunion removal, performed as part of the study. Each listing describes what is involved.