Study type
Smoking and vaping studies recruiting now
Tobacco research includes quit-smoking and quit-vaping programs, new cessation medicines and studies of how nicotine products affect the body.
161 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteers
Investigating Novel Smoking Cessation Primary Care Interventions in Rural Environments
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
Antidote Therapeutics, Inc
- Location
- Overland Park, KS
- Eligibility basics
- Ages 23–59
- RecruitingHealthy volunteersEarly Phase 1
Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults
Roswell Park Cancer Institute
- Location
- Buffalo, NY
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
Nicotinic Receptor Genetic Variation and Alcohol Reward
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 21–60
- RecruitingHealthy volunteersPhase 1
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersEarly Phase 1
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of the Electronic Cigarette Withdrawal Syndrome
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersEarly Phase 1
Smart Olfaction App to Reduce Relapse
University of Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Comparative Evaluation of Nicotine Analogs
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersPhase 1
Effect of Cannabis on E-Cigarette Use Behavior
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersEarly Phase 1
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
Duke University
- Location
- Durham, NC
- Eligibility basics
- Ages 18–21
- RecruitingHealthy volunteersPhase 1
Acute Effects of Oral Nicotine Pouches
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
Effect of Cannabis on Cigarette Use Behavior
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Age-dependent Effects of Smoked and Oral Delta-9-THC
University of California, Los Angeles
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Sex Differences in the Vascular Effects of E-cigarette Use
Anna Stanhewicz, PhD
- Location
- Iowa City, IA
- Eligibility basics
- Ages 18–24
- RecruitingHealthy volunteersEarly Phase 1
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
University of Iowa
- Location
- Iowa City, IA + 1 other US site
- Eligibility basics
- Ages 18–24
- RecruitingHealthy volunteersPhase 1/Phase 2
Hyperpolarized Xenon-129 MR Imaging of the Lung
University of Virginia
- Location
- Charlottesville, VA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System
RAI Services Company
- Location
- Fort Lauderdale, FL + 4 other US sites
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteers
Identification and Validation of Blood-Based Biomarkers for Early Detection of Asymptomatic Lung Cancer in High-Risk Heavy Smokers
Everest Detection, Inc.
- Location
- Oklahoma City, OK
- Eligibility basics
- Ages 30–80
- RecruitingHealthy volunteers
A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers
RAI Services Company
- Location
- Brandon, FL + 7 other US sites
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteers
A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
RAI Services Company
- Location
- Maitland, FL + 6 other US sites
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteers
Abuse Liability for Five Modern Oral Nicotine Products
RAI Services Company
- Location
- Overland Park, KS
- Eligibility basics
- Ages 21–60
Who these studies look for
Most require current smoking or vaping at a set level, measured at screening. Quit studies often include counseling.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Do I have to quit to join?
Cessation studies are for people who want to quit. Other tobacco studies may ask you to keep your usual habits or switch products for a period. The listing explains which.