Study type
Smoking and vaping studies recruiting now
Tobacco research includes quit-smoking and quit-vaping programs, new cessation medicines and studies of how nicotine products affect the body.
161 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteers
Collection of Sputum and Labeling for Lung Cancer
bioAffinity Technologies Inc.
- Location
- Summit, NJ + 2 other US sites
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Detection of Oral and Throat Cancers Using OralViome Cancer Testing System
Viome
- Location
- New York, NY
- Eligibility basics
- Ages 18+
- RecruitingPhase 3
Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)
Axsome Therapeutics, Inc.
- Location
- Little Rock, AR + 24 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 2
A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse
Eli Lilly and Company
- Location
- Rogers, AR + 16 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 2
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
VapeAway
- Location
- New York, NY
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Weill Medical College of Cornell University
- Location
- New York, NY
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
California State University, Northridge
- Location
- Northridge, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
Medical University of South Carolina
- Location
- Charleston, SC + 3 other US sites
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Use of Nicotine Pouches Among Daily Smokers
Milton S. Hershey Medical Center
- Location
- Hershey, PA + 1 other US site
- Eligibility basics
- Ages 21–70
- RecruitingHealthy volunteers
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
National Institute on Drug Abuse (NIDA)
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteers
Using Nicotine to Reverse Age-related Auditory Processing Deficits
University of California, Irvine
- Location
- Irvine, CA + 1 other US site
- Eligibility basics
- Ages 18–85
- RecruitingHealthy volunteers
An Educational Intervention (Lung Toolkit) for Improving Knowledge About Lung Cancer and Screening Among American Indian and Alaskan Native Cigarette Smokers, Lung PATHS Trial
Fred Hutchinson Cancer Center
- Location
- Seattle, WA
- Eligibility basics
- Ages 50–80
- RecruitingHealthy volunteersPhase 2
Ongoing Lung Decline With Age Intensified Response
Cedars-Sinai Medical Center
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteers
Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers
Nikki Nollen, PhD, MA
- Location
- Kansas City, MO
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 3
Switching to E-cigarettes in Smokers Not Interested in Quitting
University of Kansas Medical Center
- Location
- Kansas City, MO + 1 other US site
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Educating Smokers About Lung Cancer Screening Using Tobacco Quitlines
M.D. Anderson Cancer Center
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Smoking Cessation CM for Veterans With or at Risk for Cancer
VA Office of Research and Development
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
DoubleTake: Effect of Message Exposure Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes
Georgia State University
- Location
- Atlanta, GA
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
A Community Health Intervention to Improve Lung Cancer Screening Uptake in Community Health Centers
Baystate Medical Center
- Location
- Springfield, MA
- Eligibility basics
- Ages 50–80
- RecruitingHealthy volunteersPhase 2
Semaglutide for Post-Smoking Cessation Weight Management
The University of Texas Health Science Center, Houston
- Location
- Austin, TX + 1 other US site
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteers
Orexin s Role in the Neurobiology of Substance Use Disorder
National Institute on Drug Abuse (NIDA)
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteers
Temporal Interference Methods for Addiction Treatment
Indiana University
- Location
- Bloomington, IN + 1 other US site
- Eligibility basics
- Ages 21–50
- RecruitingHealthy volunteers
Trauma-Informed Care for Smoking Cessation for Pregnancy
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18+ · Women only
Who these studies look for
Most require current smoking or vaping at a set level, measured at screening. Quit studies often include counseling.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Do I have to quit to join?
Cessation studies are for people who want to quit. Other tobacco studies may ask you to keep your usual habits or switch products for a period. The listing explains which.