Study type
Smoking and vaping studies recruiting now
Tobacco research includes quit-smoking and quit-vaping programs, new cessation medicines and studies of how nicotine products affect the body.
161 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteers
A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users
Fred Hutchinson Cancer Center
- Location
- Seattle, WA
- Eligibility basics
- Ages 18–30
- RecruitingHealthy volunteers
Vaped Phenanthrene
University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Sex Differences in E-Cigarette Perception
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 21–44
- RecruitingHealthy volunteers
The Abuse Liability of IQOS Heated Tobacco Products Among Adults Who Smoke
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteers
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
- Location
- Basking Ridge, NJ + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)
Roswell Park Cancer Institute
- Location
- Buffalo, NY
- Eligibility basics
- Ages 18–25
- RecruitingHealthy volunteers
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
National Institute on Drug Abuse (NIDA)
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–99
- RecruitingHealthy volunteers
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit Trial
Fred Hutchinson Cancer Center
- Location
- Seattle, WA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 2
Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation
University of Oklahoma
- Location
- Oklahoma City, OK
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
Dana-Farber Cancer Institute
- Location
- Boston, MA
- Eligibility basics
- Any age listed
- RecruitingHealthy volunteers
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 4
THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Manipulating E-Cigarette Nicotine to Promote Public Health
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteers
Evaluating the Impact of CONNECT in a Multilingual Population
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 50–80
- RecruitingHealthy volunteers
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Implementation and Effectiveness of the BJC-Pink and Pearl Project on Lung Cancer Screening
Washington University School of Medicine
- Location
- Creve Coeur, MO
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Evaluating the Implementation and Effectiveness of the Pink and Pearl Campaign on Lung Cancer Screening at Christian Hospital
Washington University School of Medicine
- Location
- St Louis, MO
- Eligibility basics
- Ages 20+
- RecruitingHealthy volunteersPhase 2
Kick-Nic! Youth Quit Vaping App
Yale University
- Location
- New Haven, CT
- Eligibility basics
- Ages 12–19
- RecruitingHealthy volunteers
Maternal Smoking Cessation and Pediatric Obesity Prevention
State University of New York at Buffalo
- Location
- Buffalo, NY
- Eligibility basics
- Ages 18–39 · Women only
- RecruitingHealthy volunteers
Rural Smoking Cessation
Masonic Cancer Center, University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 4
My Path to Quit Tobacco
University of Wisconsin, Madison
- Location
- Milwaukee, WI
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Social Media Influences on Engagement and Susceptibility to Non-combustible Tobacco Product Use Among Youth and Young Adults (AYA)
University of Southern California
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 14–17
- RecruitingHealthy volunteers
Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 21+
Who these studies look for
Most require current smoking or vaping at a set level, measured at screening. Quit studies often include counseling.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Do I have to quit to join?
Cessation studies are for people who want to quit. Other tobacco studies may ask you to keep your usual habits or switch products for a period. The listing explains which.