Study type
Smoking and vaping studies recruiting now
Tobacco research includes quit-smoking and quit-vaping programs, new cessation medicines and studies of how nicotine products affect the body.
161 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteers
Social Media Support Groups for Adolescent Vaping Cessation
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 13+
- RecruitingHealthy volunteers
PCORI-CER-1306-03385 Lung Cancer Screening Decision Aid Development and Testing
M.D. Anderson Cancer Center
- Location
- Galveston, TX + 1 other US site
- Eligibility basics
- Ages 55–80
- RecruitingHealthy volunteersPhase 2
Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers
National Cancer Institute (NCI)
- Location
- Tucson, AZ + 2 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Lung B.A.S.E.S. 4 Life Mobile Low-dose Computed Tomography (LDCT) Screening: Ages 40-54
Wake Forest University Health Sciences
- Location
- Charlotte, NC
- Eligibility basics
- Ages 40–54
- RecruitingHealthy volunteers
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
Duke University
- Location
- Durham, NC
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteers
Switch or Quit R01
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
University of Southern California
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteers
Abuse Liability and Appeal of Oral Nicotine Products
University of Southern California
- Location
- Los Angeles, CA
- Eligibility basics
- Ages 21–25
- RecruitingHealthy volunteers
American Indian Smokefree Native RCT
Masonic Cancer Center, University of Minnesota
- Location
- Minneapolis, MN
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 2
Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking
Washington State University
- Location
- Spokane, WA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Young Adult Tobacco/Nicotine and Cannabis Co-use
Medical University of South Carolina
- Location
- Charleston, SC
- Eligibility basics
- Ages 18–25
- RecruitingHealthy volunteers
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
Ohio State University Comprehensive Cancer Center
- Location
- Columbus, OH
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 2
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
Johns Hopkins University
- Location
- Birmingham, AL
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Testing ANSOS for Efficacy in Multi-Tribal Urban Communities
Lehigh University
- Location
- Bethlehem, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Non-Invasive Deep Brain Neuromodulation for Smoking Cessation
The University of Texas Health Science Center, Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 20–60
- RecruitingHealthy volunteers
Prevention of Postpartum Smoking Relapse and Related Health Consequences by Breastfeeding Promotion
State University of New York at Buffalo
- Location
- Buffalo, NY
- Eligibility basics
- Ages 18+ · Women only
- RecruitingHealthy volunteers
Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteers
Measuring Environmental Tobacco and Cannabis: Pollutants and Exposures
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 21–50
- RecruitingHealthy volunteers
Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care
University of Florida
- Location
- Gainesville, FL
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 4
E-cigarette Cessation in Adults Who Co-use Cannabis
Medical University of South Carolina
- Location
- Charleston, SC + 2 other US sites
- Eligibility basics
- Ages 18–40
- RecruitingHealthy volunteers
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
Abramson Cancer Center at Penn Medicine
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteers
Developing and Testing Health Warning Labels on the ENDS Device
Florida International University
- Location
- Miami, FL
- Eligibility basics
- Ages 21–35
- RecruitingHealthy volunteers
The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth
University of Hawaii
- Location
- Honolulu, HI
- Eligibility basics
- Ages 10–14
- RecruitingHealthy volunteers
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers
University of California, San Francisco
- Location
- San Francisco, CA
- Eligibility basics
- Ages 40–75
Who these studies look for
Most require current smoking or vaping at a set level, measured at screening. Quit studies often include counseling.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Do I have to quit to join?
Cessation studies are for people who want to quit. Other tobacco studies may ask you to keep your usual habits or switch products for a period. The listing explains which.