Phase 1 · Maryland
Phase 1 clinical trials in Maryland
109 studies have at least one recruiting site in Maryland. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
109 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersPhase 1
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–75
- RecruitingHealthy volunteersEarly Phase 1
Psilocybin Administration With 5-HT1a Blockade
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–60
- RecruitingHealthy volunteersPhase 1
Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersPhase 1
The Pharmacokinetics of a Hemp-Based Topical Product
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Baltimore, MD + 4 other US sites
- Eligibility basics
- Any age listed
- RecruitingHealthy volunteersPhase 1
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–101
- RecruitingHealthy volunteersPhase 1
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
National Eye Institute (NEI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 5–120
- RecruitingHealthy volunteersPhase 1
Administering NMT to Reestablish Infant Nasal Microbiome Diversity Following Intranasal Mupirocin Treatment
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 0 mo–60
- RecruitingHealthy volunteersPhase 1/Phase 2
Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
National Heart, Lung, and Blood Institute (NHLBI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–120 · Women only
- RecruitingHealthy volunteersPhase 1/Phase 2
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 21–65
- RecruitingHealthy volunteersEarly Phase 1
Evaluation of the Electronic Cigarette Withdrawal Syndrome
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersEarly Phase 1
Optic Nerve Head Strain in Non-glaucoma Subjects
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 30–90
- RecruitingHealthy volunteersPhase 1
Cabotegravir-Hormone PK/PD Interactions for HIV Prevention
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 19+
- RecruitingHealthy volunteersPhase 1/Phase 2
Vasopressin and Pain Perception in the Brain
University of Maryland, Baltimore
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Location
- Baltimore, MD + 1 other US site
- Eligibility basics
- Ages 19+ · Women only
- RecruitingHealthy volunteersEarly Phase 1
Measuring Acute Drug Demand in Humans
University of Maryland, Baltimore
- Location
- Baltimore, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Controlled Human Infection Study of Orally Administered Trichuris Trichiura Eggs in Naïve Adults
George Washington University
- Location
- Bethesda, MD + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 1
Behavioral Pharmacology of Orally Administered THC and D-limonene
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–55
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–65
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.