Phase 1 · Massachusetts
Phase 1 clinical trials in Massachusetts
101 studies have at least one recruiting site in Massachusetts. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
101 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial
Wandercraft
- Location
- Boston, MA
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)
Splice Bio
- Location
- Boston, MA + 4 other US sites
- Eligibility basics
- Ages 12–65
- RecruitingPhase 1
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
Ascentage Pharma Group Inc.
- Location
- Boston, MA + 6 other US sites
- Eligibility basics
- Ages 18–85
- RecruitingPhase 1
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
Tenaya Therapeutics
- Location
- Boston, MA + 6 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
Spirovant Sciences, Inc.
- Location
- Boston, MA + 3 other US sites
- Eligibility basics
- Ages 18–65
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.