Skip to content
Bored Studies
RecruitingPhase 2

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Eli Lilly and Company · NCT06143956

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
1481
US sites recruiting
43
Study start
November 17, 2023
Record last updated
October 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.

Being studied: LY3305677; LY3841136; Tirzepatide; LY3549492; LY3532226; Placebo; Placebo

Conditions: Obesity; Overweight

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Have a body mass index (BMI)
  • ≥30 kilogram/square meter (kg/m²), or
  • ≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity
  • Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss.

Exclusion Criteria

  • Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening.
  • Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
  • Have poorly controlled hypertension.
  • Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
  • Have any of the following cardiovascular conditions within 3 months prior to screening:
  • acute myocardial infarction
  • cerebrovascular accident (stroke)
  • unstable angina, or
  • hospitalization due to congestive heart failure.
  • Have a history of symptomatic gallbladder disease within the past 2 years.
  • Have a lifetime history of suicide attempts.

Recruiting US locations

  • The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

    Chandler, AZ 85225

    Site contact: Yessica Sachdeva

  • Headlands Research - Scottsdale

    Scottsdale, AZ 85260

    Site contact: 480-725-8708

  • The Institute for Liver Health II dba Arizona Liver Health-Tucson

    Tucson, AZ 85712

    Site contact: 480-470-4000

  • NorCal Medical Research, Inc

    Greenbrae, CA 94904

    Site contact: 415-461-1585

  • Velocity Clinical Research, Huntington Park

    Huntington Park, CA 90255

    Site contact: 323-588-1990

  • Peninsula Research Associates

    Rolling Hills Estates, CA 90274

    Site contact: 310-265-1623

  • Diablo Clinical Research, Inc.

    Walnut Creek, CA 94598

    Site contact: 925-930-7267

  • Stamford Therapeutics Consortium

    Stamford, CT 06905

    Site contact: David Radin

  • New Horizon Research Center

    Miami, FL 33165

    Site contact: 305-226-3933

  • Indago Research & Health Center, Inc

    Miami Lakes, FL 33016

    Site contact: 305-825-6588

  • Suncoast Clinical Research, Inc.

    New Port Richey, FL 34652

    Site contact: 727-849-4131

  • Charter Research - Winter Park

    Orlando, FL 32803

    Site contact: 407-337-3000

  • Charter Research - Lady Lake

    The Villages, FL 32162

    Site contact: 352-441-2000

  • Medical Research Partners

    Ammon, ID 83406

    Site contact: 208-681-9070

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, IL 60640

    Site contact: 773-275-3500 Ext 162

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, IA 50266

    Site contact: 515-329-6800

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, KS 66606

    Site contact: 785-354-9591

  • Monroe Biomedical Research - Louisville

    Louisville, KY 40213

    Site contact: 502-515-5672

  • Knownwell

    Needham, MA 02492

    Site contact: 339-793-8998

  • Lucida Clinical Trials

    New Bedford, MA 02740

    Site contact: 508-720-2015

  • Headlands Research - Detroit

    Southfield, MI 48034

    Site contact: Christopher Romero

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, MI 48098

    Site contact: 248-312-0025

  • StudyMetrix Research

    City of Saint Peters, MO 63303

    Site contact: 636-387-5100

  • Clinvest Headlands Llc

    Springfield, MO 65807

    Site contact: Christina Capps

  • Las Vegas Medical Research

    Las Vegas, NV 89128

    Site contact: 702-750-0000

  • Dent Neurologic Institute

    Amherst, NY 14226

    Site contact: Laszlo Mechtler

  • Velocity Clinical Research, Syracuse

    East Syracuse, NY 13057

    Site contact: Rachel Dubroff

  • Rochester Clinical Research, LLC

    Rochester, NY 14609

    Site contact: 585-288-0890

  • Medication Management

    Greensboro, NC 27401

    Site contact: 336-763-6968

  • Monroe Biomedical Research

    Monroe, NC 28112

    Site contact: 704-283-7359

  • Lucas Research, Inc

    Morehead City, NC 28557

    Site contact: 252-222-5700

  • Lucas Research, Inc.

    New Bern, NC 28562

    Site contact: 252-649-1944

  • CTI Clinical Research Center

    Cincinnati, OH 45212

    Site contact: 513-721-3868

  • Tribe Clinical Research, LLC

    Greenville, SC 29607

    Site contact: 864-334-0141

  • Quality Medical Research

    Nashville, TN 37211

    Site contact: 615-835-4750

  • IMA Clinical Research Austin

    Austin, TX 78745

    Site contact: 512-649-0082

  • Velocity Clinical Research, Dallas

    Dallas, TX 75230

    Site contact: Dan Lender

  • FutureSearch Trials of Dallas

    Dallas, TX 75251

    Site contact: 214-369-2600

  • PlanIt Research, PLLC

    Houston, TX 77079

    Site contact: 713-973-3415

  • Endeavor Clinical Trials

    San Antonio, TX 78240

    Site contact: 518-428-6859

  • Texas Valley Clinical Research

    Weslaco, TX 78596

    Site contact: 956-431-8090

  • Sovah Clinical Research-River District

    Danville, VA 24541

    Site contact: 434-793-4711

  • Central Washington Health Services Association d/b/a Confluence Health

    Wenatchee, WA 98801

    Site contact: 509-436-4050

Study contacts (from the official record)

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 1-317-615-4559 · LillyTrials@Lilly.com
  • Physicians interested in becoming principal investigators please contact · clinical_inquiry_hub@lilly.com
All weight loss studies in Arizona →
A Master Protocol Study (LY900038) of Multiple… (NCT06143956) | Bored Studies