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RecruitingPhase 2

A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

AbbVie · NCT06972446

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
180
US sites recruiting
49
Study start
June 20, 2025
Record last updated
October 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA).

This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide.

There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

Being studied: Lutikizumab; Placebo; Ravagalimab

Conditions: Rheumatoid Arthritis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • At any time prior to the Screening Visit, participant must have been treated for > or = 3 months with at least 1 b/tsDMARD therapy but continued to exhibit active RA, or had to discontinue due to intolerability or toxicity, irrespective of treatment duration. The maximum cap for prior use of b/tsDMARD is 2.
  • Participant must be on a stable dose of methotrexate (MTX)

Exclusion Criteria

  • Participant is taking nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen/paracetamol, low-potency opioids (tramadol, codeine, hydrocodone, alone or in combination with acetaminophen), oral corticosteroids (equivalent to ≤ 10 mg/day of prednisone), or inhaled corticosteroids for stable medical conditions unless they have been on stable doses for ≥ 1 week prior to Baseline Visit.
  • History of any arthritis with onset prior to age 17 years or current diagnosis of inflammatory joint disease other than rheumatoid arthritis.

Recruiting US locations

  • Sun Valley Arthritis Center /ID# 278331

    Peoria, AZ 85381

  • Arthritis And Rheumatism Associates (Ara) - Jonesboro /ID# 272896

    Jonesboro, AR 72401

  • Private Practice - Dr. David S. Hallegua /ID# 277608

    Beverly Hills, CA 90211

  • Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826

    Chula Vista, CA 91910

    Site contact: Site Coordinator · 619-334-4735

  • Newport Huntington Medical Group /ID# 272439

    Huntington Beach, CA 92648-5994

  • Cohen Medical Centers /ID# 278341

    Thousand Oaks, CA 91360

  • The Lundquist Institute /ID# 272481

    Torrance, CA 90502

  • Inland Rheumatology and Osteoporosis Medical Group /ID# 272449

    Upland, CA 91786

  • Tekton Research - Fort Collins - East Harmony Road /ID# 272472

    Fort Collins, CO 80528

  • Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 272298

    Avon Park, FL 33825

  • Clinical Research Of West Florida - Phase I Unit /ID# 272428

    Clearwater, FL 33765

  • Finlay Medical Research - Greenacres /ID# 281654

    Greenacres City, FL 33467

  • Neoclinical Research - Hialeah /ID# 272070

    Hialeah, FL 33016

  • South Florida Rheumatology /ID# 278339

    Hollywood, FL 33026

  • Swati Shah, MD Rheumatology /ID# 273624

    Jacksonville, FL 32257

  • Life Clinical Trials - Colonial Drive - Margate /ID# 272589

    Margate, FL 33063

  • HMD Research LLC /ID# 272432

    Orlando, FL 32819

  • Vitalia Research /ID# 272478

    Palm Beach Gardens, FL 33410

  • Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 272755

    Tampa, FL 33606

    Site contact: Site Coordinator · 813-870-1292

  • Northwestern Medicine - Northwestern Memorial Hospital /ID# 275422

    Chicago, IL 60611

  • Deerbrook Medical Associates /ID# 273439

    Libertyville, IL 60048

  • Advanced Quality Medical Research /ID# 277824

    Orland Park, IL 60462

  • Arnold Arthritis & Rheumatology /ID# 278354

    Skokie, IL 60076

  • Willow Rheumatology and Wellness /ID# 272691

    Willowbrook, IL 60527

  • Accurate Clinical Research (SMO/Network/Consortium) /ID# 272650

    Lake Charles, LA 70605

  • AA Medical Research Center - Grand Blanc /ID# 272496

    Grand Blanc, MI 48439

  • Sahni Rheumatology & Therapy /ID# 278352

    West Long Branch, NJ 07764

  • Albuquerque Center For Rheumatology /ID# 272301

    Albuquerque, NM 87102

  • Northwell Health Physician Partners Rheumatology At Great Neck /ID# 275621

    Great Neck, NY 11021

  • Joint And Muscle Research Institute /ID# 277290

    Charlotte, NC 28204

  • DJL Clinical Research - Charlotte /ID# 272387

    Charlotte, NC 28211-1064

  • Paramount Medical Research and Consulting /ID# 272474

    Middleburg Heights, OH 44130

  • Altoona Center For Clinical Research /ID# 272479

    Duncansville, PA 16635

    Site contact: Site Coordinator · 814-693-0300

  • Low Country Rheumatology /ID# 277607

    Summerville, SC 29486

  • West Tennessee Research Institute /ID# 272453

    Jackson, TN 38305

  • Tekton Research - West Gate /ID# 272270

    Austin, TX 78745

  • Trinity Universal Research Associates - Carrollton /ID# 272577

    Carrollton, TX 75007

  • Arthritis Care Of Texas /ID# 277961

    Corpus Christi, TX 78415

    Site contact: Site Coordinator · 713-487-8680

  • Arthritis and Rheumatology Research Institute - Frisco /ID# 272299

    Frisco, TX 75035

  • Accurate Clinical Research - Houston /ID# 272271

    Houston, TX 77089-6142

  • Private Practice - Dr. Laila A. Hassan /ID# 272297

    Houston, TX 77089

  • Care & Cure Clinic /ID# 281684

    Houston, TX 77909

    Site contact: Site Coordinator · 832-234-1023

  • Biopharma Informatic /ID# 279189

    Katy, TX 77494

  • Southwest Rheumatology Research /ID# 272268

    Mesquite, TX 75150

    Site contact: Site Coordinator · 972-288-2600

  • Texas Rheumatology Research Institute /ID# 278010

    Plano, TX 75024

  • Epic Medical Research /ID# 272656

    Red Oak, TX 75154

  • Fort Bend Rheumatology Associates /ID# 280761

    Sugar Land, TX 77479

  • DM Clinical Research - Tomball /ID# 272452

    Tomball, TX 77375

  • Dm Clinical Research -Tomball Rch /ID# 281787

    Tomball, TX 77377

Study contacts (from the official record)

  • ABBVIE CALL CENTER · 844-663-3742 · abbvieclinicaltrials@abbvie.com
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A Study to Evaluate Different Targeted Therapies for Patients With… (NCT06972446) | Bored Studies