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RecruitingPhase 2

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Eli Lilly and Company · NCT07589608

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
400
US sites recruiting
40
Study start
May 15, 2026
Record last updated
October 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Being studied: Macupatide; Eloralintide; Placebo

Conditions: Overweight; Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • See Master Protocol CWMM (NCT06143956) for inclusion criteria

Exclusion Criteria

In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):

  • Have type 1 diabetes or type 2 diabetes
  • Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
  • Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
  • Have a history of acute or chronic pancreatitis
  • All concomitant medications should be at a stable dose for at least 3 months prior to screening

Recruiting US locations

  • The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

    Chandler, AZ 85225

    Site contact: Yessica Sachdeva

  • Headlands Research - Scottsdale

    Scottsdale, AZ 85260

    Site contact: Benjamin Clark

  • The Institute for Liver Health II dba Arizona Liver Health-Tucson

    Tucson, AZ 85712

    Site contact: Anita Kohli

  • NorCal Medical Research, Inc

    Greenbrae, CA 94904

    Site contact: Linda Gaudiani

  • Velocity Clinical Research, Huntington Park

    Huntington Park, CA 90255

    Site contact: Stanley Hsia

  • Peninsula Research Associates

    Rolling Hills Estates, CA 90274

    Site contact: LeighAnn Schmidt

  • Diablo Clinical Research, Inc.

    Walnut Creek, CA 94598

    Site contact: Bonnie Kimmel

  • Stamford Therapeutics Consortium

    Stamford, CT 06905

    Site contact: David Radin

  • New Horizon Research Center

    Miami, FL 33165

    Site contact: Lazaro Nunez

  • Indago Research & Health Center, Inc

    Miami Lakes, FL 33016

    Site contact: Jose Cardona

  • Suncoast Clinical Research, Inc.

    New Port Richey, FL 34652

    Site contact: Cathy Barnes

  • Charter Research - Winter Park

    Orlando, FL 32803

    Site contact: Edgardo Rivera-Rivera

  • Charter Research - Lady Lake

    The Villages, FL 32162

    Site contact: Jeffrey Norton

  • Medical Research Partners

    Ammon, ID 83406

    Site contact: Joseph Moore

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, IL 60640

    Site contact: Rupal Trivedi

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, KS 66606

    Site contact: susan brian

  • Monroe Biomedical Research - Louisville

    Louisville, KY 40213

    Site contact: Harold Bays

  • Knownwell

    Needham, MA 02492

    Site contact: Angela Fitch

  • Lucida Clinical Trials

    New Bedford, MA 02740

    Site contact: David Shih

  • Headlands Research - Detroit

    Southfield, MI 48034

    Site contact: Christopher Romero

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, MI 48098

    Site contact: Neil Fraser

  • StudyMetrix Research

    City of Saint Peters, MO 63303

    Site contact: Timothy Smith

  • Clinvest Headlands Llc

    Springfield, MO 65807

    Site contact: Christina Capps

  • Las Vegas Medical Research

    Las Vegas, NV 89128

    Site contact: Cornell Calinescu

  • Dent Neurologic Institute

    Amherst, NY 14226

    Site contact: Laszlo Mechtler

  • Rochester Clinical Research, LLC

    Rochester, NY 14609

    Site contact: Patrick Connors

  • Medication Management

    Greensboro, NC 27401

    Site contact: James Franklin

  • Monroe Biomedical Research

    Monroe, NC 28112

    Site contact: Awawu Igbinadolor

  • Lucas Research, Inc

    Morehead City, NC 28557

    Site contact: Kathryn Lucas

  • Lucas Research, Inc.

    New Bern, NC 28562

    Site contact: Joseph Maides

  • CTI Clinical Research Center

    Cincinnati, OH 45212

    Site contact: James Maynard

  • Tribe Clinical Research, LLC

    Greenville, SC 29607

    Site contact: Ronald Mayfield

  • Quality Medical Research

    Nashville, TN 37211

    Site contact: Saras Sharma

  • IMA Clinical Research Austin

    Austin, TX 78745

    Site contact: Nomita Kim

  • FutureSearch Trials of Dallas

    Dallas, TX 75251

    Site contact: Michael Downing

  • PlanIt Research, PLLC

    Houston, TX 77079

    Site contact: Amer Al-Karadsheh

  • Endeavor Clinical Trials

    San Antonio, TX 78240

    Site contact: Nitendra Agarwal

  • Texas Valley Clinical Research

    Weslaco, TX 78596

    Site contact: Eduardo Luna

  • Sovah Clinical Research-River District

    Danville, VA 24541

    Site contact: Stephan Jannach

  • Central Washington Health Services Association d/b/a Confluence Health

    Wenatchee, WA 98801

    Site contact: Kathryn Eren

Study contacts (from the official record)

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 317-615-4559 · LillyTrials@Lilly.com
  • Physicians interested in becoming principal investigators please contact · clinical_inquiry_hub@lilly.com
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A Study to Investigate Weight Management With Macupatide and… (NCT07589608) | Bored Studies