Phase 1 · Tennessee
Phase 1 clinical trials in Tennessee
49 studies have at least one recruiting site in Tennessee. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
49 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingPhase 1/Phase 2
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
Ionis Pharmaceuticals, Inc.
- Location
- Nashville, TN + 7 other US sites
- Eligibility basics
- Ages 2–65 · Men only
- RecruitingPhase 1/Phase 2
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Sumitomo Pharma America, Inc.
- Location
- Nashville, TN + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures
Jazz Pharmaceuticals
- Location
- Memphis, TN + 20 other US sites
- Eligibility basics
- Ages 12–75
- RecruitingPhase 1/Phase 2
A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia
Kyowa Kirin Co., Ltd.
- Location
- Nashville, TN + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
AbbVie
- Location
- Cordova, TN + 10 other US sites
- Eligibility basics
- Ages 50–90
- RecruitingPhase 1/Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company, Inc.
- Location
- Chattanooga, TN + 44 other US sites
- Eligibility basics
- Ages 12–35
- RecruitingPhase 1
A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines
AbbVie
- Location
- Nashville, TN + 7 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome
Ionis Pharmaceuticals, Inc.
- Location
- Memphis, TN + 4 other US sites
- Eligibility basics
- Ages 2–12
- RecruitingPhase 1/Phase 2
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
Locate Bio Pty Ltd
- Location
- Nashville, TN + 2 other US sites
- Eligibility basics
- Ages 22–80
- RecruitingPhase 1/Phase 2
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
4D Molecular Therapeutics
- Location
- Nashville, TN + 19 other US sites
- Eligibility basics
- Ages 50+
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Smyrna, TN + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingPhase 1/Phase 2
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
AviadoBio Ltd
- Location
- Nashville, TN + 2 other US sites
- Eligibility basics
- Ages 30–75
- RecruitingPhase 1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
Cullinan Therapeutics Inc.
- Location
- Memphis, TN + 5 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and…
AbbVie
- Location
- Memphis, TN + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1
Study of BHV-1300 in Graves' Disease
Biohaven Therapeutics Ltd.
- Location
- Memphis, TN + 9 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
AC Immune SA
- Location
- Cordova, TN + 3 other US sites
- Eligibility basics
- Ages 35–85
- RecruitingPhase 1
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
UCB Biopharma SRL
- Location
- Jackson, TN + 29 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Alexion Pharmaceuticals, Inc.
- Location
- Nashville, TN + 9 other US sites
- Eligibility basics
- Ages 18+
- RecruitingEarly Phase 1
VTP-1000 in Adults With Celiac Disease
Barinthus Biotherapeutics
- Location
- Nashville, TN + 15 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity
MBX Biosciences
- Location
- Knoxville, TN + 3 other US sites
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1/Phase 2
Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
Recursion Pharmaceuticals Inc.
- Location
- Nashville, TN + 6 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Fate Therapeutics
- Location
- Memphis, TN + 15 other US sites
- Eligibility basics
- Ages 12–70
- RecruitingPhase 1/Phase 2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion
AbbVie
- Location
- Nashville, TN + 11 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Amylyx Pharmaceuticals Inc.
- Location
- Knoxville, TN + 9 other US sites
- Eligibility basics
- Ages 18+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.