Phase 1 · Texas
Phase 1 clinical trials in Texas
202 studies have at least one recruiting site in Texas. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
202 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Regeneron Pharmaceuticals
- Location
- Houston, TX + 4 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
A Study to Learn More About the Safety of BIIB145 and How it is Processed in the Body of Healthy Adult Participants
Biogen
- Location
- Austin, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Phase 1 Study of ABF-101 in Single- and Multiple-Ascending Doses
Aptabio Therapeutics, Inc.
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants
ViiV Healthcare
- Location
- Austin, TX + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of VH4011499 Compared to Placebo in Adults Without HIV
ViiV Healthcare
- Location
- Austin, TX + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
An Advanced Decision Support Tool for Personalized Medicine for IVF Using Modeling and Optimization for Provera
Urmila DIwekar
- Location
- Houston, TX + 1 other US site
- Eligibility basics
- Ages 20–50 · Women only
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Vega Therapeutics, Inc
- Location
- Dallas, TX + 9 other US sites
- Eligibility basics
- Ages 12–60
- RecruitingHealthy volunteersPhase 1
Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever
HDT Bio
- Location
- San Antonio, TX
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)
Exelixis
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–75
- RecruitingPhase 1Overnight stay mentioned
A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia
Leal Therapeutics, Inc
- Location
- Richardson, TX + 9 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingPhase 1Overnight stay mentioned
Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder
BioXcel Therapeutics Inc
- Location
- DeSoto, TX + 3 other US sites
- Eligibility basics
- Ages 10–17
- RecruitingPhase 1Overnight stay mentioned
MAD Study to Assess the Safety, Tolerability, PKs and Efficacy of YJ001 for Spray Use in Patients With DPNP
Zhejiang Hanmai Pharmaceutical Technology Co., Ltd.
- Location
- Fredericksburg, TX
- Eligibility basics
- Ages 18–80
- RecruitingHealthy volunteersPhase 1
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Galveston, TX + 4 other US sites
- Eligibility basics
- Ages 18–64
- RecruitingHealthy volunteersPhase 1
Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML
Montefiore Medical Center
- Location
- Houston, TX + 1 other US site
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersEarly Phase 1
Pharmacological Modulation of Brain Oscillations in Memory Processing
University of Texas Southwestern Medical Center
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1/Phase 2
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Baylor College of Medicine
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use
Christopher D. Verrico
- Location
- Houston, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1/Phase 2
A Phase I-II Study Investigating the All-Oral Combination of the Menin Inhibitor SNDX-5613 With Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)
M.D. Anderson Cancer Center
- Location
- Houston, TX
- Eligibility basics
- Ages 12+
- RecruitingHealthy volunteersPhase 1
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Texas A&M University
- Location
- Houston, TX + 1 other US site
- Eligibility basics
- Ages 21–45
- RecruitingHealthy volunteersPhase 1/Phase 2
Annatto-derived GG for Statin-associated Myopathy
Texas Tech University Health Sciences Center
- Location
- Lubbock, TX
- Eligibility basics
- Ages 40+
- RecruitingHealthy volunteersEarly Phase 1
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
University of Texas Southwestern Medical Center
- Location
- Dallas, TX
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Houston, TX + 4 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Houston, TX + 4 other US sites
- Eligibility basics
- Any age listed
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.