Phase 1 · Texas
Phase 1 clinical trials in Texas
202 studies have at least one recruiting site in Texas. Phase 1 (and early Phase 1) trials are usually the first time a medicine is studied in people. They are typically small, closely monitored, and many are run in dedicated research units, sometimes with overnight stays.
202 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1
Thymalfasin (Thymosin Alpha 1; Ta1) as an Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 Vaccine
The Methodist Hospital Research Institute
- Location
- Houston, TX
- Eligibility basics
- Ages 65–100
- RecruitingHealthy volunteersEarly Phase 1
Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy
Texas Tech University Health Sciences Center
- Location
- Lubbock, TX
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Smart Olfaction App to Reduce Relapse
University of Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
MTOR Inhibitors in Older Adults
University of Texas Southwestern Medical Center
- Location
- Dallas, TX
- Eligibility basics
- Ages 65–80
- RecruitingHealthy volunteersPhase 1
Protocol Title: Safety and Feasibility of Autologous CD34+ Hematopoietic Stem Cells Mobilization and Apheresis in Participants With RUNX1 Familial Platelet Disorder
M.D. Anderson Cancer Center
- Location
- Houston, TX
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersEarly Phase 1
Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
University of Texas at Austin
- Location
- Austin, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Hormones, Outcomes, and Pain Pathways in Exercise Study
University of Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 18–60 · Women only
- RecruitingHealthy volunteersEarly Phase 1
RESTOR: PK/PD mTORi Inhibition in Older Adults
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX
- Eligibility basics
- Ages 65–90
- RecruitingHealthy volunteersPhase 1
An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy
M.D. Anderson Cancer Center
- Location
- Houston, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
ACT for Individuals With MNCD and Their Care Partners
Texas Tech University
- Location
- Lubbock, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Exploration of an Online Education Program to Support Caregivers' Knowledge Transfer
Texas Christian University
- Location
- Fort Worth, TX
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1/Phase 2
Curcumin and Retinal Study
Texas Tech University Health Sciences Center
- Location
- Lubbock, TX
- Eligibility basics
- Ages 40–89
- RecruitingHealthy volunteersEarly Phase 1
Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersEarly Phase 1
The Effects of Bariatric Surgeries on Glucose Metabolism
The University of Texas Health Science Center at San Antonio
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
B-Complex: A Nutraceutical SANS Countermeasure
National Aeronautics and Space Administration (NASA)
- Location
- Houston, TX
- Eligibility basics
- Ages 20–100
- RecruitingHealthy volunteersPhase 1
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: a Dimensional Approach
The University of Texas Health Science Center, Houston
- Location
- Houston, TX
- Eligibility basics
- Ages 18–80
- RecruitingPhase 1/Phase 2
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Encoded Therapeutics
- Location
- Fort Worth, TX + 9 other US sites
- Eligibility basics
- Ages 6 mo–17
- RecruitingPhase 1
A Study About the Safety of a Single ASP2020 Eye Injection and if it Helps People With Vision Loss From Stargardt-type Eye Conditions
Astellas Institute for Regenerative Medicine
- Location
- Dallas, TX + 3 other US sites
- Eligibility basics
- Ages 6+
- RecruitingPhase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Two Formulations of ASC36 Injection in Participants With Obesity or Overweight
Ascletis Pharma (China) Co., Limited
- Location
- San Antonio, TX + 1 other US site
- Eligibility basics
- Ages 18–65
- RecruitingPhase 1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Cullinan Therapeutics Inc.
- Location
- Plano, TX + 10 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B
Regeneron Pharmaceuticals
- Location
- Dallas, TX + 16 other US sites
- Eligibility basics
- Ages 2+ · Men only
- RecruitingPhase 1/Phase 2
An AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM)
Affinia Therapeutics
- Location
- Houston, TX + 3 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingPhase 1/Phase 2
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Sanofi
- Location
- Arlington, TX + 30 other US sites
- Eligibility basics
- Ages 60+
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Are Phase 1 trials riskier?
Every study carries risk. Phase 1 studies involve less human data about the product, which is why they are closely monitored. The informed consent document explains the known risks; read it carefully and ask questions before signing.
Why do some Phase 1 studies include overnight stays?
Staying in the unit lets staff dose on a precise schedule and collect samples around the clock. Where a record mentions an inpatient stay we flag it on the listing.